STIMULATION OF EPIDERMAL HYALURONAN BY YEAST FERMENT.

• TR Number: 488
• Keywords: Aging, Elasticity, EpiDerm-FT, EpiDermFT, Hyaluronan, Hydration, ROS, Reactive oxygen, Reactive oxygen species, Wrinkle formation

This study by researchers at Procter & Gamble Co. demonstrated how Mattek’s EpiDermFT full-thickness in vitro human skin tissue equivalent can be used to study the expression of a major extracellular matrix component of human skin (hyaluronan), and can also be used to trace hyaluronan expression to cells in the epidermal layer. INTRODUCTION: Hyaluronan is a major component of the extracellular matrix of skin, responsible for maintaining overall hydration and elasticity. A decline in epidermal hyaluronan content occurs during aging, contributing to decreased turgidity and increased wrinkle formation. Yeast Ferment Filtrate reduces generation of reactive oxygen species in skin cells in vitro. In the current work, scientists at Procter & Gamble Co. examined additional skin cell responses to Yeast Ferment Filtrate, with focus on hyaluronan. CONCLUSIONS: Yeast Ferment Filtrate increased the expression of hyaluronan in EpiDerm-FT human skin equivalent cultures. The increased hyaluronan was located in the epidermis of the cultures. These results indicate that Yeast Ferment Filtrate increases hyaluronan expression by cultured skin, specifically epidermal cells.