Genotoxicity

Use MatTek’s EpiDerm model with the COMET or Micronucleus assays to assess genotoxic potential of chemicals or other formulations.

The Model

MatTek’s patented EpiDerm™ System consists of normal, human-derived epidermal keratinocytes (NHEK) which have been cultured to form a multilayered, highly differentiated model of the human epidermis. These “ready-to-use” tissues are cultured on specially prepared cell culture inserts using serum free medium, and attain levels of differentiation on the cutting edge of in vitro skin technology. Ultrastructurally, the EpiDerm Skin Model closely parallels human skin, thus providing a useful in vitro means to assess dermal irritancy and toxicology.

Download a featured reference on the COMET and Micronucleus Assays.

Download a featured reference on the Micronucleus Assay.

For more information, view Technical References.

Learn more about EpiDerm.