Join us for a FREE webinar on NAMs-Based Prediction of Respiratory Toxicity Using Human and Rat Airway Models
Join us Wednesday, April 9th at 9:30am EST
Can’t make it? All registrants will automatically receive an email with the recording.
Charles River Laboratories, in partnership with MatTek Life Sciences, is developing a New Approach Methodology (NAM) inhalation toxicology test to reduce reliance on traditional animal research methods, as presented in a poster presented at this year’s Society of Toxicology Annual Meeting. Our presenters will discuss the results of this phase of the project, plans for the next phases of the project, goals for the project, and the changing testing landscape.
This webinar reviews the first phase of the project which evaluated the acute toxicity of a panel of chemicals with known inhalation risk assessment categories in 2D and 3D human airway models, as well as a 3D rat airway epithelial model. This work is part of a larger program which also includes repeat dose responses, aerosol vs liquid applications, and donor differences, with the eventual goal of generating a prediction model for inhalation risk of aerosol chemicals.
We will host a Q&A session at the conclusion of the presentation, and the webinar will be recorded and available online. Links for the recording and all companion material will be automatically provided to all registrants, regardless of live attendance.
Meet Our Panelists:
Dr. Seyoum Ayehunie
Chief Scientific Officer
MatTek Life Sciences
Head of Discovery Toxicology and Pharmacology
Charles River Laboratories
Dr. Mary McElroy is Head of Discovery Toxicology and Pharmacology at Charles River Laboratories, Edinburgh. In this capacity, Mary’s team run in vitro safety assessments studies including lung organotypic cultures for human relevant risk assessment by inhalation route and are co-investigators on an American Chemical Council with MatTek. Prior to Charles River, Mary spent her career performing lung-related cell-biology, pharmacology, and toxicology. Mary has an MSc in Toxicology from University of Surrey, PhD in Human Lung Development from the University of Southampton, post-doctoral research on alveolar epithelial cell biology at University of California San Francisco, Lecturer/Group Leader positions at the Trinity Collage Dublin and University of Edinburgh. Mary is a European Registered Toxicologist and holds an MBA from the Open University. Connect on LinkedIn
