Tissue Models

EpiKidney™ (beta)

MatTek’s human 3D in vitro kidney model is disrupting the pharmacokinetics research space as an easy-to-use, physiologically active renal proximal tubule microphysiological system.

EpiNasal™ (beta)

EpiNasal is a ready-to-use, 3D tissue model cultured using normal, human-derived nasal epithelial cells to provide researchers with a human-relevant, in vitro nasal system. EpiNasal recapitulates the in vivo mucociliary phenotype and its barrier, and infection and toxicity responses parallel those of native tissue. Cultured at the air liquid interface, EpiNasal allows for physiological exposures to pathogens, chemicals, and therapeutics.

EpiAlveolar™

EpiAlveolar is a 3D co-culture model of the air-blood barrier. Produced from primary human alveolar epithelial cells, pulmonary endothelial cells and fibroblasts, EpiAlveolar is a in vitro model system developed to mimic human-relevant biological responses.

Psoriasis

Psoriasis is a chronic inflammatory skin disease characterized by epidermal hyperplasia (Acanthosis). MatTek has developed an in vitro model of Psoriasis to enable the study of the disease, and to screen therapeutic candidates for safety and efficacy.

Melanoma

An in vitro model of melanoma enables oncologists and cancer researchers a better understanding of disease progression, and an efficient platform for testing new therapies.

MelanoDerm™

Ideal for the assessment of skin brightening agents and formulations, MelanoDerm is used by cosmetic scientists worldwide. Reduce the time and costs associated with clinical testing by screening compounds and formulations in MatTek’s MelanoDerm 3D tissue model.

EpiVaginal™

EpiVaginal provides an in vitro research tool both for feminine product safety testing and for the study of HIV-1 and other sexually transmitted diseases. Its tissue structure and cellular physiology closely parallel in vivo vaginal epithelial tissue, making it ideal for toxicology and efficacy testing, as well as a tool for biological research.

EpiOral™ & EpiGingival™

Various industrial and toxicology laboratories are actively seeking alternatives to expensive clinical or whole animal testing. Oral care, personal care, and pharmaceutical companies have initiated in vitro toxicology testing to evaluate their raw materials and final product formulations.

EpiOcular™

EpiOcular’s exceptional reproducibility provides scientists with quantifiable assessments of irritation. Its correlation to in vivo sensitivity makes it an ideal alternative to in vivo testing for toxicological evaluation of raw materials and final formulations.

EpiIntestinal™

MatTek’s 3D tissue model of the human small intestine is advancing in vitro GI research worldwide. Allowing for physiological exposures and human-relevant endpoints, EpiIntestinal is being added to pharmaceutical development and microbiome discovery programs worldwide. Key features:

• Epithelial Polarity
• Highly Differentiated, Physiologically Relevant
• Multiple Donors Available
• Delivered Ready-to-use & Easy-to-use

EpiDerm™

MatTek’s patented EpiDerm system is the leading in vitro testing technology for dermal toxicologists and formulation scientists. With multiple ECVAM validations and OECD accepted test guidelines, EpiDerm is a proven in vitro model system for chemical, pharmaceutical and skin care product testing.

EpiCorneal™

One of the newest MatTek tissue models. Initial data indicates that EpiCorneal tissue model can effectively provide a non-animal means to assess ocular irritation, drug delivery, endomicrobial and other infections, as well as wound healing and tissue regeneration studies.

EpiAirway™

MatTek’s 3D tissue models of the human airway are advancing in vitro respiratory research worldwide. Allowing for physiological exposures to pathogens, chemicals or therapeutics, EpiAirway’s human-relevant biological responses are changing the way scientists research respiratory diseases and drug development. Let EpiAirway advance your science.

EpiDermFT™

The development of innovative skin care products requires advanced, human-relevant in vitro testing technologies. When world leading personal care and cosmetic scientists evaluate novel ingredients and formulations, they choose the EpiDermFT 3D human skin model.