Reference Libraries

April 9, 2025

Qualification of the human Reconstructed Intestine Micronuclei Cytome assay for site-of-contact genotoxic hazard identification

While valuable for hazard identification, in vitro genotoxicity tests that are conducted in 2D monolayer cell cultures possess limitations to accurately envisage in vivo outcomes and may result in unnecessary follow-up in vivo studies. One limitation is their relevance to actual human exposure and the assessment... Read More

April 3, 2025

Potassium 4-Methoxysalicylate (4MSK) Exerts a Skin Lightening Effect by Acting on Melanocytes and Keratinocytes

Background: Hyperpigmentation is a common acquired disorder that can be a cosmetic concern for many individuals. To reduce and prevent hyperpigmentation, numerous skin lightening agents have been developed. Potassium 4-methoxysalicylate (4MSK) is a skin lightening agent that was approved as... Read More

April 2, 2025

Human organotypic colon in vitro microtissue: unveiling a new window into colonic drug disposition

The purpose of this study was to evaluate EpiColon, a novel human organotypic 3D colon microtissue prototype, developed to assess colonic drug disposition, with a particular focus on permeability ranking, and compare its performance to Caco-2 monolayers. EpiColon was characterized... Read More

April 2, 2025

In Vitro Inhalation Toxicity Assay of Azoxystrobin 23% SC and Spinetoram 11.7% SC using EpiAirwayTM

Inhalation is one of the major routes for the evaluation of hazards of a xenobiotic since the lung is an important route for exposure of chemicals and crop protection products. Crop protection products, such as Azoxystrobin 23% SC and Spinetoram... Read More

April 2, 2025

Worldwide reproducibility of a highly differentiated 3-dimensional vaginal tissue model for testing of feminine hygiene products

When making risk and hazard assessments of new ingredients or finished products, reproducibility of the toxicology test system is of extreme importance to regulators, in-house toxicologists, and formulation scientists. One of the advantages of in vitro test systems vis-à-vis animal-based... Read More

Reference Libraries

Qualification of the human Reconstructed Intestine Micronuclei Cytome assay for site-of-contact genotoxic hazard identification

Potassium 4-Methoxysalicylate (4MSK) Exerts a Skin Lightening Effect by Acting on Melanocytes and Keratinocytes

Human organotypic colon in vitro microtissue: unveiling a new window into colonic drug disposition

In Vitro Inhalation Toxicity Assay of Azoxystrobin 23% SC and Spinetoram 11.7% SC using EpiAirwayTM

Worldwide reproducibility of a highly differentiated 3-dimensional vaginal tissue model for testing of feminine hygiene products

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