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16-Kauren-2-beta-18,19-triol inhibits melanosome transport in melanocytes by down-regulation of melanophilin expression

Cheol Hwan Myung, Kyuri Kim, Jong Il Park, Ji Eun Lee, Jeong Ah Lee, Sung Chan Hong, Kyung-Min Lim, Jae Sung Hwang
Abstract

Rab27a, Mlph, and MyoVa form a tripartite complex and relate to melanosome distribution. Melanophilin (Mlph) acts as a linker protein between Rab27a and MyoVa. The biological activity and function of 16-kauren on the expression of Mlph has not yet been studied.

Keywords

MelanoDerm (MEL-300-B), skin pigmentation, depigmenting agent, plant-derived diterpenoid, MelanA/ MART-1, Lightness L-value , Macro observation, histology, Fontana Masson, melanosome transport,

Materials Tested

16-Kauren, plant-derived diterpenoid

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