Basket-weave structure in the stratum corneum is an important factor for maintaining the physiological properties of human skin as studied using reconstructed human epidermis and tape stripping of human cheek skin

The normal stratum corneum (SC) has an upper basket-weave (BW) pattern layer and a lower compact layer. The transition from compact to BW SC is well associated with a transition from diffuse to peripheral distributions of corneodesmosomes (CDs). The loss of transition from compact SC to BW SC appears to cause structural and barrier-function impairments.

EPI-201, stratum corneum, basket-weave, corneo-desmosomes, intercellular lipids, mechanical properties, multilamellar lipid sheets, tactile sensor, desmoglein 1, lamellar lipids

oil-in-water emulsion, petroleum jelly, glycerin, butylene glycol, Cyclopentasiloxane, Quaternium-18 hectorite, polyethylene glycol-10 dimethicone, polyethylene glycol -2 stearate, stearic acid