Reference Libraries

August 27, 2024

Toxicity and Inflammatory Response to Common Magic Mouthwashes in a 3D Oral Reconstructed Tissue Model

Magic Mouthwash is a general term describing oral rinses prescribed by a doctor for the treatment of pain, inflammation, or infection, commonly as a result of chemotherapy and radiation induced oral sores (oral mucositis). There is no set combination of... Read More

August 27, 2024

Safety assessment of monographed OTC cold/cough medicine using an in vitro testing platform based on human reconstructed oral tissues

Over-the-counter (OTC) products are available to alleviate concurrent symptoms of colds and flu. They are primarily based on a combination of decongestants, antitussive and alpha adrenergic agonists, which are well-established pharmaceutical agents covered by U.S. monographs. Many of the active... Read More

August 26, 2024

Deoxyvasicinone with Anti-Melanogenic Activity from Marine-Derived Streptomyces sp. CNQ-617

The tricyclic quinazoline alkaloid deoxyvasicinone (DOV, 1) was isolated from a marinederived Streptomyces sp. CNQ-617, and its anti melanogenic effects were investigated. Deoxyvasicinone was shown to decrease the melanin content of B16F10 and MNT-1 cells that have been stimulated by... Read More

August 26, 2024

An Evaluation of the EpiDerm™ Corrosivity and Corrositex® Assays for Predicting Skin Corrosivity of Chemical Products with Extreme Alkaline pH

The purpose of this study was to evaluate the EpiDerm™ Corrosivity (OECD 431) and Corrositex® Time Monitor (OECD 435) as in vitro methods to predict skin corrosivity for extreme pH (≥ 11.5) products. Extreme pH can be a useful predictor... Read More

August 26, 2024

Ocular side effects of systemic medications: utilization of the 3D human corneal epithelial tissue model

Many systemic medications administered at high doses have the potential to induce unwanted ocular effects, including light sensitivity, pain, or corneal edema that are due to inflammation and/or cytotoxicity. Current drug screening experiments utilize animal models which are not suitable... Read More

Reference Libraries

Toxicity and Inflammatory Response to Common Magic Mouthwashes in a 3D Oral Reconstructed Tissue Model

Safety assessment of monographed OTC cold/cough medicine using an in vitro testing platform based on human reconstructed oral tissues

Deoxyvasicinone with Anti-Melanogenic Activity from Marine-Derived Streptomyces sp. CNQ-617

An Evaluation of the EpiDerm™ Corrosivity and Corrositex® Assays for Predicting Skin Corrosivity of Chemical Products with Extreme Alkaline pH

Ocular side effects of systemic medications: utilization of the 3D human corneal epithelial tissue model

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