Reference Libraries

December 11, 2015

THE SKIN CANCER CHEMOTHERAPEUTIC AGENT INGENOL-3-ANGELATE (PEP005) IS A SUBSTRATE FOR THE EPIDERMAL MULTIDRUG TRANSPORTER (ABCB1) AND TARGETS TUMOR VASCULATURE.

Ingenol-3-angelate (Ing3A), extracted from Euphorbia peplus, is currently in clinical trials for eradicating basal cell carcinoma, actinic keratosis, and squamous cell carcinoma (SCC) in situ by topical application. Although structurally related to phorbol esters and a protein kinase C activator,... Read More

December 11, 2015

SURFACTANT-LIKE PROPERTIES OF ALKALINE EXTRACTS FROM WASTEWATER BIOSOLIDS.

In order to assess the potential for utilizing wastewater biosolids as a source of useful substances, the surface activity of materials extracted from wastewater biosolids (activated sludge) by simple incubation with sodium hydroxide solutions at room temperature was assessed. The... Read More

December 11, 2015

USE OF THE EPIAIRWAY MODEL FOR CHARACTERIZING LONG-TERM HOST-PATHOGEN INTERACTIONS.

Nontypeable Haemophilus influenzae (NTHi) are human-adapted Gram-negative bacteria that can cause recurrent and chronic infections of the respiratory mucosa 1; 2. To study the mechanisms by which these organisms survive on and inside respiratory tissues, a model in which successful... Read More

December 11, 2015

COMPARISON OF CORROSITEX AND EPIDERM IN VITRO SKIN CORROSION SCREENING ASSAYS TO IN VIVO CORROSIVITY RESULTS.

This study by researchers at Dow Chemical Co. demonstrated that MatTek’s EpiDerm human skin tissue equivalent gave near-perfect concordance with in vivo corrosivity data for a panel of 12 reference chemicals recommended in OECD Guideline 431. In this study, Dow... Read More

December 11, 2015

IN VITRO SKIN CORROSION TEST: LONG TERM REPRODUCIBILITY AND RELIABILITY FOR A REGULATORY ACCEPTED METHOD.

This study by scientists at the Institute for In Vitro Sciences (IIVS) and MatTek Corp. demonstrated the long term reproducibility and reliability of MatTek’s EpiDerm tissue model and the EpiDerm Dermal Corrosion assay protocol, as required by regulators. The EpiDerm... Read More

Reference Libraries

THE SKIN CANCER CHEMOTHERAPEUTIC AGENT INGENOL-3-ANGELATE (PEP005) IS A SUBSTRATE FOR THE EPIDERMAL MULTIDRUG TRANSPORTER (ABCB1) AND TARGETS TUMOR VASCULATURE.

SURFACTANT-LIKE PROPERTIES OF ALKALINE EXTRACTS FROM WASTEWATER BIOSOLIDS.

USE OF THE EPIAIRWAY MODEL FOR CHARACTERIZING LONG-TERM HOST-PATHOGEN INTERACTIONS.

COMPARISON OF CORROSITEX AND EPIDERM IN VITRO SKIN CORROSION SCREENING ASSAYS TO IN VIVO CORROSIVITY RESULTS.

IN VITRO SKIN CORROSION TEST: LONG TERM REPRODUCIBILITY AND RELIABILITY FOR A REGULATORY ACCEPTED METHOD.

Get the latest