Reference Libraries

December 11, 2015

USE OF THE EPIAIRWAY MODEL FOR CHARACTERIZING LONG-TERM HOST-PATHOGEN INTERACTIONS.

Nontypeable Haemophilus influenzae (NTHi) are human-adapted Gram-negative bacteria that can cause recurrent and chronic infections of the respiratory mucosa 1; 2. To study the mechanisms by which these organisms survive on and inside respiratory tissues, a model in which successful... Read More

December 11, 2015

THE SKIN CANCER CHEMOTHERAPEUTIC AGENT INGENOL-3-ANGELATE (PEP005) IS A SUBSTRATE FOR THE EPIDERMAL MULTIDRUG TRANSPORTER (ABCB1) AND TARGETS TUMOR VASCULATURE.

Ingenol-3-angelate (Ing3A), extracted from Euphorbia peplus, is currently in clinical trials for eradicating basal cell carcinoma, actinic keratosis, and squamous cell carcinoma (SCC) in situ by topical application. Although structurally related to phorbol esters and a protein kinase C activator,... Read More

December 11, 2015

A TRIPLE CELL CO-CULTURE MODEL OF THE AIR-BLOOD BARRIER RECONSTRUCTED FROM PRIMARY HUMAN CELLS.

Reliable in vitro human models for investigating airway toxicity are needed to advance Tox21 efforts to replace animal testing with human-based model systems. In vitro airway models based on primary human cells have been described, however, models based on animal... Read More

December 11, 2015

Phenotypic Responses of Differentiated Asthmatic Human Airway Epithelial Cultures to Rhinovirus

Objectives: Human airway epithelial cells are the principal target of human rhinovirus (HRV), a common cold pathogen that triggers the majority of asthma exacerbations. The objectives of this study were 1) to evaluate an in vitro air liquid interface cultured... Read More

December 11, 2015

ADAPTATION OF HUMAN PARAINFLUENZA VIRUS TO AIRWAY EPITHELIUM REVEALS FUSION PROPERTIES REQUIRED FOR GROWTH IN HOST TISSUE.

Paramyxoviruses, a family of RNA enveloped viruses that includes human parainfluenza virus type 3 (HPIV3), cause the majority of childhood croup, bronchiolitis, and pneumonia worldwide. Infection starts with host cell receptor binding and fusion of the viral envelope with the... Read More

Reference Libraries

USE OF THE EPIAIRWAY MODEL FOR CHARACTERIZING LONG-TERM HOST-PATHOGEN INTERACTIONS.

THE SKIN CANCER CHEMOTHERAPEUTIC AGENT INGENOL-3-ANGELATE (PEP005) IS A SUBSTRATE FOR THE EPIDERMAL MULTIDRUG TRANSPORTER (ABCB1) AND TARGETS TUMOR VASCULATURE.

A TRIPLE CELL CO-CULTURE MODEL OF THE AIR-BLOOD BARRIER RECONSTRUCTED FROM PRIMARY HUMAN CELLS.

Phenotypic Responses of Differentiated Asthmatic Human Airway Epithelial Cultures to Rhinovirus

ADAPTATION OF HUMAN PARAINFLUENZA VIRUS TO AIRWAY EPITHELIUM REVEALS FUSION PROPERTIES REQUIRED FOR GROWTH IN HOST TISSUE.

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