Reference Libraries

December 11, 2015

ADAPTATION OF HUMAN PARAINFLUENZA VIRUS TO AIRWAY EPITHELIUM REVEALS FUSION PROPERTIES REQUIRED FOR GROWTH IN HOST TISSUE.

Paramyxoviruses, a family of RNA enveloped viruses that includes human parainfluenza virus type 3 (HPIV3), cause the majority of childhood croup, bronchiolitis, and pneumonia worldwide. Infection starts with host cell receptor binding and fusion of the viral envelope with the... Read More

December 11, 2015

A TRIPLE CELL CO-CULTURE MODEL OF THE AIR-BLOOD BARRIER RECONSTRUCTED FROM PRIMARY HUMAN CELLS.

Reliable in vitro human models for investigating airway toxicity are needed to advance Tox21 efforts to replace animal testing with human-based model systems. In vitro airway models based on primary human cells have been described, however, models based on animal... Read More

December 11, 2015

THE SKIN CANCER CHEMOTHERAPEUTIC AGENT INGENOL-3-ANGELATE (PEP005) IS A SUBSTRATE FOR THE EPIDERMAL MULTIDRUG TRANSPORTER (ABCB1) AND TARGETS TUMOR VASCULATURE.

Ingenol-3-angelate (Ing3A), extracted from Euphorbia peplus, is currently in clinical trials for eradicating basal cell carcinoma, actinic keratosis, and squamous cell carcinoma (SCC) in situ by topical application. Although structurally related to phorbol esters and a protein kinase C activator,... Read More

December 11, 2015

SURFACTANT-LIKE PROPERTIES OF ALKALINE EXTRACTS FROM WASTEWATER BIOSOLIDS.

In order to assess the potential for utilizing wastewater biosolids as a source of useful substances, the surface activity of materials extracted from wastewater biosolids (activated sludge) by simple incubation with sodium hydroxide solutions at room temperature was assessed. The... Read More

December 11, 2015

IN VITRO SKIN CORROSION TEST: LONG TERM REPRODUCIBILITY AND RELIABILITY FOR A REGULATORY ACCEPTED METHOD.

This study by scientists at the Institute for In Vitro Sciences (IIVS) and MatTek Corp. demonstrated the long term reproducibility and reliability of MatTek’s EpiDerm tissue model and the EpiDerm Dermal Corrosion assay protocol, as required by regulators. The EpiDerm... Read More

Reference Libraries

ADAPTATION OF HUMAN PARAINFLUENZA VIRUS TO AIRWAY EPITHELIUM REVEALS FUSION PROPERTIES REQUIRED FOR GROWTH IN HOST TISSUE.

A TRIPLE CELL CO-CULTURE MODEL OF THE AIR-BLOOD BARRIER RECONSTRUCTED FROM PRIMARY HUMAN CELLS.

THE SKIN CANCER CHEMOTHERAPEUTIC AGENT INGENOL-3-ANGELATE (PEP005) IS A SUBSTRATE FOR THE EPIDERMAL MULTIDRUG TRANSPORTER (ABCB1) AND TARGETS TUMOR VASCULATURE.

SURFACTANT-LIKE PROPERTIES OF ALKALINE EXTRACTS FROM WASTEWATER BIOSOLIDS.

IN VITRO SKIN CORROSION TEST: LONG TERM REPRODUCIBILITY AND RELIABILITY FOR A REGULATORY ACCEPTED METHOD.

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