Reference Libraries

December 11, 2015

RECONSTRUCTED HUMAN SKIN MODEL TO STUDY MELANOMA AT DIFFERENT STAGES OF PROGRESSION.

This study by scientists at MatTek Corp. demonstrated that MatTek’s EpiDerm-FT in vitro human full-thickness skin tissue equivalent can be co-cultured with melanocytes at different stages of malignancy to produce three dimensional, serum-free tissue culture models that can be used... Read More

December 11, 2015

FLAVONOIDS DIFFERENTIALLY REGULATE IFN-GAMMA-INDUCED ICAM-1 EXPRESSION IN HUMAN KERATINOCYTES: MOLECULAR MECHANISMS OF ACTION.

The effect of plant flavonoids on intercellular adhesion molecule-1 (ICAM-1) expression in human keratinocyte was investigated. ICAM-1 is known to mediate skin inflammation. Among the flavonoids tested, taxifolin was the most potent in inhibiting interferon γ (IFN γ)-induced ICAM-1 protein... Read More

December 11, 2015

A SMALL-MOLECULE E2F INHIBITOR BLOCKS GROWTH IN A MELANOMA CULTURE MODEL.

This study by researchers at the H. Lee Moffitt Cancer Center and Research Institute demonstrated how MatTek’s Melanoma in vitro human skin tissue equivalent can be used to investigate both the efficacy of potential melanoma therapeutic agents and their potential... Read More

December 11, 2015

HUMAN SKIN EQUIVALENT: A RELIABLE IN VITRO MODEL FOR CARCINOGENIC EXPERIMENTS.

EpiDermFT (MatTek Co., MA) is an in vitro model for human skin derived from keratinocytes of human neonatal foreskin. The epidermal component is cultured to form a highly differentiated model of metabolically and mitotically active cells that are arranged analogous... Read More

December 11, 2015

UPREGULATION OF SOX9 INHIBITS THE GROWTH OF HUMAN AND MOUSE MELANOMAS AND RESTORES THEIR SENSITIVITY TO RETINOIC ACID.

This study by researchers at the National Cancer Institute (NIH) demonstrated that MatTek’s Melanoma in vitro human skin tissue equivalent can be used to investigate both the efficacy and cytotoxicity of potential malignant melanoma treatments. Treatments for primary and metastatic... Read More

Reference Libraries

RECONSTRUCTED HUMAN SKIN MODEL TO STUDY MELANOMA AT DIFFERENT STAGES OF PROGRESSION.

FLAVONOIDS DIFFERENTIALLY REGULATE IFN-GAMMA-INDUCED ICAM-1 EXPRESSION IN HUMAN KERATINOCYTES: MOLECULAR MECHANISMS OF ACTION.

A SMALL-MOLECULE E2F INHIBITOR BLOCKS GROWTH IN A MELANOMA CULTURE MODEL.

HUMAN SKIN EQUIVALENT: A RELIABLE IN VITRO MODEL FOR CARCINOGENIC EXPERIMENTS.

UPREGULATION OF SOX9 INHIBITS THE GROWTH OF HUMAN AND MOUSE MELANOMAS AND RESTORES THEIR SENSITIVITY TO RETINOIC ACID.

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