Reference Libraries

December 11, 2015

INFLUENCE OF SOYBEAN SYMBIOSOME EXTRACT ON UV-INDUCED SKIN FREE-RADICAL BIOCHEMISTRY.

This study by researchers at Arch Personal Care Products, Arch Chemicals, Bioinnovation Laboratories, Inc., and Dermscan Group demonstrated how MatTek’s EpiDermFT full-thickness in vitro human skin tissue equivalent can be used to measure the ability of a topically-applied formulation to... Read More

December 11, 2015

PHOTOPROTECTIVE EFFECT OF ISOFLAVONE GENISTEIN ON ULTRAVIOLET B-INDUCED PYRIMIDINE DIMER FORMATION AND PCNA EXPRESSION IN HUMAN RECONSTITUTED SKIN AND ITS IMPLICATIONS IN DERMATOLOGY AND PREVENTION OF CUTANEOUS CARCINOGENESIS.

This study by researchers at Mount Sinai School of Medicine demonstrated that MatTek’s EpiDermFT epidermal/dermal human skin tissue equivalent can be used to investigate the photoprotective efficacy of compounds by exposing treated and untreated EpiDermFT tissues to UVB radiation. Genistein,... Read More

December 11, 2015

FLAVONOIDS DIFFERENTIALLY REGULATE IFN-GAMMA-INDUCED ICAM-1 EXPRESSION IN HUMAN KERATINOCYTES: MOLECULAR MECHANISMS OF ACTION.

The effect of plant flavonoids on intercellular adhesion molecule-1 (ICAM-1) expression in human keratinocyte was investigated. ICAM-1 is known to mediate skin inflammation. Among the flavonoids tested, taxifolin was the most potent in inhibiting interferon γ (IFN γ)-induced ICAM-1 protein... Read More

December 11, 2015

EVIDENCE THAT NITRIC OXIDE IS AN UPSTREAM MEDIATOR OF FASL-MEDIATED KERATINOCYTE APOPTOSIS IN TOXIC EPIDERMAL NECROLYSIS.

Toxic epidermal necrolysis (TEN or Lyell’s syndrome) is a severe adverse drug reaction that results in extensive necrolysis of the skin due to large scale Fas-FasL mediated keratinocyte apoptosis. The signaling pathways leading to the rapid upregulation of keratinocyte FasL... Read More

December 11, 2015

JAGGED-1 MEDIATED ACTIVATION OF NOTCH SIGNALING INDUCES COMPLETE MATURATION OF HUMAN KERATINOCYTES THROUGH NF-B AND PPARγ.

Establishing an effective epidermal barrier requires a series of coordinated molecular events involving keratinocytes (KCs) within a stratified epithelium. Epidermal maturation depends on convergence of pathways involving components of NF-B and peroxisome proliferator activated receptor (PPAR) signaling systems that promote... Read More

Reference Libraries

INFLUENCE OF SOYBEAN SYMBIOSOME EXTRACT ON UV-INDUCED SKIN FREE-RADICAL BIOCHEMISTRY.

PHOTOPROTECTIVE EFFECT OF ISOFLAVONE GENISTEIN ON ULTRAVIOLET B-INDUCED PYRIMIDINE DIMER FORMATION AND PCNA EXPRESSION IN HUMAN RECONSTITUTED SKIN AND ITS IMPLICATIONS IN DERMATOLOGY AND PREVENTION OF CUTANEOUS CARCINOGENESIS.

FLAVONOIDS DIFFERENTIALLY REGULATE IFN-GAMMA-INDUCED ICAM-1 EXPRESSION IN HUMAN KERATINOCYTES: MOLECULAR MECHANISMS OF ACTION.

EVIDENCE THAT NITRIC OXIDE IS AN UPSTREAM MEDIATOR OF FASL-MEDIATED KERATINOCYTE APOPTOSIS IN TOXIC EPIDERMAL NECROLYSIS.

JAGGED-1 MEDIATED ACTIVATION OF NOTCH SIGNALING INDUCES COMPLETE MATURATION OF HUMAN KERATINOCYTES THROUGH NF-B AND PPARγ.

Get the latest