Reference Libraries

Establishing an effective epidermal barrier requires a series of coordinated molecular events involving keratinocytes (KCs) within a stratified epithelium. Epidermal maturation depends on convergence of pathways involving components of NF-B and peroxisome proliferator activated receptor (PPAR) signaling systems that promote... Read More

Cyclooxygenase-2 (COX-2) appears to play an important role in skin carcinogenesis caused by solar ultraviolet radiation (UVR): UVR induces COX-2 expression in human skin, COX-2 activity is upregulated in skin cancers and COX inhibitors reduce UVR-induced tumor formation. In this... Read More

The signaling system regulating the highly coordinated and programmed series of molecular events that generate a mature, fully differentiated and cornified epidermis is unknown. To determine if Notch ligands and receptors that regulate cell fate decisions in other organ systems... Read More

Recently we established that peptides derived from the Notch ligand-Jagged-1 could trigger complete epidermal differentiation using submerged living epidermal equivalents (EEs). Moreover, using a selective inhibitor designed to block Notch receptor activity, epidermal differentiation was also blocked when submerged EEs... Read More

Toxic epidermal necrolysis (TEN or Lyell’s syndrome) is a severe adverse drug reaction that results in extensive necrolysis of the skin due to large scale Fas-FasL mediated keratinocyte apoptosis. The signaling pathways leading to the rapid upregulation of keratinocyte FasL... Read More