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December 11, 2015

CHARACTERIZATION OF APOPTOTIC MACHINERY CONTROLLING CELL DEATH IN EPIDERMIS.

Ironically, the functional integrity of epidermis is dependent on a “planned cell death” pathway by which keratinocytes (KCs) undergo terminal differentiation, and then die producing comeocytes. To explore the molecular basis for crucial steps regulating epidermal KC cell death, normal... Read More

December 11, 2015

MODELLING THE HUMAN BRONCHI AND ITS RESPONSES IN VITRO.

This study by researchers at Unilever’s Safety and Environment Assurance Centre (SEAC) demonstrated that MatTek’s EpiAirway in vitro human tracheal/bronchial tissue equivalent displayed significant morphological and biochemical correlation with both in vitro and in vivo models, re-confirming the potential value... Read More

December 11, 2015

SULFUR MUSTARD-INDUCED RESPONSES OF AIRWAY AND SKIN IN VITRO.

Sulfur mustard (SM) is a vesicant that has been used in warfare and is a potential threat to civilians either from acts of terrorism or through accidental exposure to abandoned military caches of the chemical. Exposure of the skin produces... Read More

December 11, 2015

HYPERPIGMENTATION IN HUMAN SOLAR LENTIGO IS PROMOTED BY HEPARANASE-INDUCED LOSS OF HEPARAN SULFATE CHAINS AT THE DERMAL–EPIDERMAL JUNCTION.

Background: Skin pigmentation induced by ultraviolet B radiation is caused in part by inflammation mediated by cytokines secreted from keratinocytes and fibroblasts in the irradiated area. Heparanase is also activated in the irradiated skin, and this leads to loss of... Read More

December 11, 2015

FGF2 REGULATES MELANOCYTES VIABILITY THROUGH THE STAT3-TRANSACTIVATED PAX3 TRANSCRIPTION.

PAX3 (paired box 3) is known to have an important role in melanocyte development through modulation of microphthalmiaassociated transcription factor transcription. Here we found that PAX3 transcriptional activity could be regulated through FGF2 (basic fibroblast growth factor)-STAT3 (signal transducer and... Read More

Reference Libraries

CHARACTERIZATION OF APOPTOTIC MACHINERY CONTROLLING CELL DEATH IN EPIDERMIS.

MODELLING THE HUMAN BRONCHI AND ITS RESPONSES IN VITRO.

SULFUR MUSTARD-INDUCED RESPONSES OF AIRWAY AND SKIN IN VITRO.

HYPERPIGMENTATION IN HUMAN SOLAR LENTIGO IS PROMOTED BY HEPARANASE-INDUCED LOSS OF HEPARAN SULFATE CHAINS AT THE DERMAL–EPIDERMAL JUNCTION.

FGF2 REGULATES MELANOCYTES VIABILITY THROUGH THE STAT3-TRANSACTIVATED PAX3 TRANSCRIPTION.

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