Reference Libraries

December 11, 2015

QUANTITATIVE PHOSPHOPROTEOMICS IDENTIFIES FILAGGRIN AND OTHER TARGETS OF IONIZING RADIATION IN A HUMAN SKIN MODEL.

Our objective here was to perform a quantitative phosphoproteomic study on a reconstituted human skin tissue to identify low- and high-dose ionizing radiation-dependent signalling in a complex three-dimensional setting. Application of an isobaric labelling strategy using sham and three radiation... Read More

December 11, 2015

QUALITY ASSURANCE FOR IN VITRO ALTERNATIVE TEST METHODS: QUALITY CONTROL ISSUES IN TEST KIT PRODUCTION.

In vitro toxicology methods are being adopted by regulatory agencies worldwide. Many of these methods have been validated by using proprietary materials, often in the form of test kits. Guidelines for the use of Good Laboratory Practice methods for in... Read More

December 11, 2015

ROLE OF TAURINE ACCUMULATION IN KERATINOCYTE HYDRATION.

Epidermal keratinocytes are exposed to a low water concentration at the stratum corneum stratum granulosum interface. When epithelial tissues are osmotically perturbed, cellular protection and cell volume regulation is mediated by accumulation of organic osmolytes such as taurine. Previous studies... Read More

December 11, 2015

LONG TERM CULTURE OF PSEUDOSTRATIFIED TRACHEAL BRONCHIAL EPIAIRWAY™ TISSUES.

This study by scientists at MatTek Corp. demonstrated that MatTek’s EpiAirway in vitro human tracheal/bronchial tissue equivalent remains viable for up to 27 DAYS and can therefore be used in long term studies of chronic respiratory diseases. The highly differentiated... Read More

December 11, 2015

HYPERPIGMENTATION IN HUMAN SOLAR LENTIGO IS PROMOTED BY HEPARANASE-INDUCED LOSS OF HEPARAN SULFATE CHAINS AT THE DERMAL–EPIDERMAL JUNCTION.

Background: Skin pigmentation induced by ultraviolet B radiation is caused in part by inflammation mediated by cytokines secreted from keratinocytes and fibroblasts in the irradiated area. Heparanase is also activated in the irradiated skin, and this leads to loss of... Read More

Reference Libraries

QUANTITATIVE PHOSPHOPROTEOMICS IDENTIFIES FILAGGRIN AND OTHER TARGETS OF IONIZING RADIATION IN A HUMAN SKIN MODEL.

QUALITY ASSURANCE FOR IN VITRO ALTERNATIVE TEST METHODS: QUALITY CONTROL ISSUES IN TEST KIT PRODUCTION.

ROLE OF TAURINE ACCUMULATION IN KERATINOCYTE HYDRATION.

LONG TERM CULTURE OF PSEUDOSTRATIFIED TRACHEAL BRONCHIAL EPIAIRWAY™ TISSUES.

HYPERPIGMENTATION IN HUMAN SOLAR LENTIGO IS PROMOTED BY HEPARANASE-INDUCED LOSS OF HEPARAN SULFATE CHAINS AT THE DERMAL–EPIDERMAL JUNCTION.

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