Reference Libraries

December 11, 2015

THE SERINE PROTEASE MARAPSIN IS EXPRESSED IN STRATIFIED SQUAMOUS EPITHELIA AND IS UP-REGULATED IN THE HYPERPROLIFERATIVE EPIDERMIS OF PSORIASIS AND REGENERATING WOUNDS.

The trypsin-like serine protease marapsin is a member of the large protease gene cluster at human chromosome 16p13.3, which also contains the structurally related proteases testisin, tryptase €, tryptase γ, and EOS. To gain insight into the biological functions of... Read More

December 11, 2015

THREE DIMENSIONAL (3D) RECONSTRUCTED PSORIATIC TISSUE MODEL.

Psoriasis is a chronic skin disease that affects about 2% of the global population. Availability of well characterized in vitro psoriatic tissue model will enhance our understanding of the disease and the development of therapeutic strategies. In this study, an... Read More

December 11, 2015

DELPHINIDIN INDUCES EPIDERMAL DIFFERENTIATION AND INHIBITS PROLIFERATION AND INFLAMMATION IN A THREE-DIMENSIONAL RECONSTITUTED SKIN MODEL OF PSORIASIS.

Psoriasis is a chronic, inflammatory skin disease characterized by epidermal hyperproliferation and aberrant keratinocyte differentiation. Several lines of evidence suggest that intrinsic alterations of the epidermis may play an important role in the pathogenesis of psoriasis. Identification of natural agents... Read More

December 11, 2015

AN IN VITRO METHOD TO EVALUATE THE ANTIOXIDANT EFFICACY OF TOPICAL FORMULATIONS.

We have developed a method of evaluating antioxidant efficacy in vitro using a three dimensional epidermal construct (MatTek EPI-100, MatTek Corpora-tion, Ashland, MA) which contains a well defined stratum corneum with a lipid profile similar to human skin. The EPI-100... Read More

December 11, 2015

HYPERPIGMENTATION IN HUMAN SOLAR LENTIGO IS PROMOTED BY HEPARANASE-INDUCED LOSS OF HEPARAN SULFATE CHAINS AT THE DERMAL–EPIDERMAL JUNCTION.

Background: Skin pigmentation induced by ultraviolet B radiation is caused in part by inflammation mediated by cytokines secreted from keratinocytes and fibroblasts in the irradiated area. Heparanase is also activated in the irradiated skin, and this leads to loss of... Read More

Reference Libraries

THE SERINE PROTEASE MARAPSIN IS EXPRESSED IN STRATIFIED SQUAMOUS EPITHELIA AND IS UP-REGULATED IN THE HYPERPROLIFERATIVE EPIDERMIS OF PSORIASIS AND REGENERATING WOUNDS.

THREE DIMENSIONAL (3D) RECONSTRUCTED PSORIATIC TISSUE MODEL.

DELPHINIDIN INDUCES EPIDERMAL DIFFERENTIATION AND INHIBITS PROLIFERATION AND INFLAMMATION IN A THREE-DIMENSIONAL RECONSTITUTED SKIN MODEL OF PSORIASIS.

AN IN VITRO METHOD TO EVALUATE THE ANTIOXIDANT EFFICACY OF TOPICAL FORMULATIONS.

HYPERPIGMENTATION IN HUMAN SOLAR LENTIGO IS PROMOTED BY HEPARANASE-INDUCED LOSS OF HEPARAN SULFATE CHAINS AT THE DERMAL–EPIDERMAL JUNCTION.

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