Reference Libraries

December 11, 2015

ACTIVATION OF NOTCH SIGNALING IN KERATINOCYTES (KC’S) IS NECESSARY AND SUFFICIENT TO CREATE MATURE HUMAN EPIDERMIS.

The signaling system regulating the highly coordinated and programmed series of molecular events that generate a mature, fully differentiated and cornified epidermis is unknown. To determine if Notch ligands and receptors that regulate cell fate decisions in other organ systems... Read More

December 11, 2015

EXPRESSION OF CYCLOOXYGENASE IN THE EPIDERM™ HUMAN SKIN MODEL: REGULATION BY ULTRAVIOLET RADIATION AND CYTOKINES.

Cyclooxygenase-2 (COX-2) appears to play an important role in skin carcinogenesis caused by solar ultraviolet radiation (UVR): UVR induces COX-2 expression in human skin, COX-2 activity is upregulated in skin cancers and COX inhibitors reduce UVR-induced tumor formation. In this... Read More

December 11, 2015

DELPHINIDIN INDUCES EPIDERMAL DIFFERENTIATION AND INHIBITS PROLIFERATION AND INFLAMMATION IN A THREE-DIMENSIONAL RECONSTITUTED SKIN MODEL OF PSORIASIS.

Psoriasis is a chronic, inflammatory skin disease characterized by epidermal hyperproliferation and aberrant keratinocyte differentiation. Several lines of evidence suggest that intrinsic alterations of the epidermis may play an important role in the pathogenesis of psoriasis. Identification of natural agents... Read More

December 11, 2015

INHIBITION OF TUMOUR NECROSIS FACTOR-Á SECRETION FROM EPIDERM TISSUES BY A NOVEL SMALL MOLECULE, UTL-5D.

This study by scientists at Unitech Pharmaceuticals, Wayne State University, BioInnovation Laboratories, and the Taiwan National Defense Medical Center demonstrated that MatTek’s EpiDerm in vitro 3-D human skin tissue equivalent could be used to study the dose-dependent reduction of TNF-á... Read More

December 11, 2015

PREVALIDATION OF THE EPIDERM PHOTOTOXCITY TEST.

The EpiDerm™ phototoxicity test was chosen for prevalidation within ECVAM’s tiered prevalidation procedure, since production of the full human in vitro skin model Skin2™ had been ceased in October 1996. ZEBET had developed a test protocol of a Skin2 phototoxicity... Read More

Reference Libraries

ACTIVATION OF NOTCH SIGNALING IN KERATINOCYTES (KC’S) IS NECESSARY AND SUFFICIENT TO CREATE MATURE HUMAN EPIDERMIS.

EXPRESSION OF CYCLOOXYGENASE IN THE EPIDERM™ HUMAN SKIN MODEL: REGULATION BY ULTRAVIOLET RADIATION AND CYTOKINES.

DELPHINIDIN INDUCES EPIDERMAL DIFFERENTIATION AND INHIBITS PROLIFERATION AND INFLAMMATION IN A THREE-DIMENSIONAL RECONSTITUTED SKIN MODEL OF PSORIASIS.

INHIBITION OF TUMOUR NECROSIS FACTOR-Á SECRETION FROM EPIDERM TISSUES BY A NOVEL SMALL MOLECULE, UTL-5D.

PREVALIDATION OF THE EPIDERM PHOTOTOXCITY TEST.

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