Reference Libraries

December 11, 2015

THREE DIMENSIONAL (3D) RECONSTRUCTED PSORIATIC TISSUE MODEL.

Psoriasis is a chronic skin disease that affects about 2% of the global population. Availability of well characterized in vitro psoriatic tissue model will enhance our understanding of the disease and the development of therapeutic strategies. In this study, an... Read More

December 11, 2015

EBSELEN IS A NEW SKIN DEPIGMENTING AGENT THAT INHIBITS MELANIN BIOSYNTHESIS AND MELANOSOMAL TRANSFER.

We assessed the ability of ebselen, a glutathione peroxidase mimic, to reduce pigmentation in various models. In murine B16 melanocytes, 25 µm ebselen inhibited melanogenesis and induced a depolymerisation of actin filaments. In co-cultures of B16 melanocytes with BDVII keratinocytes,... Read More

December 11, 2015

HYPERPIGMENTATION IN HUMAN SOLAR LENTIGO IS PROMOTED BY HEPARANASE-INDUCED LOSS OF HEPARAN SULFATE CHAINS AT THE DERMAL–EPIDERMAL JUNCTION.

Background: Skin pigmentation induced by ultraviolet B radiation is caused in part by inflammation mediated by cytokines secreted from keratinocytes and fibroblasts in the irradiated area. Heparanase is also activated in the irradiated skin, and this leads to loss of... Read More

December 11, 2015

USE OF THE MATTEK EPI-100 IN VITRO SYSTEM TO SCREEN ANTIOXIDANT EFFICACY.

In this study, scientists at R. Thomas Stephens & Associates present an in vitro method to evaluate the efficacy of antioxidants and antioxidant formulations. The premise of this research is that exposure of human skin equivalents, specifically the commercially available... Read More

December 11, 2015

PREVALIDATION OF THE EPIDERM PHOTOTOXICITY TEST (ED-PT).

The EpiDerm™ phototoxicity test was chosen for prevalidation within ECVAM’s tiered prevalidation procedure. In phase 1, ZEBET drafted an SOP and project plan for conducting the study. ZEBET’s task in phase I was to adapt the existing Skin2 methodology to... Read More

Reference Libraries

THREE DIMENSIONAL (3D) RECONSTRUCTED PSORIATIC TISSUE MODEL.

EBSELEN IS A NEW SKIN DEPIGMENTING AGENT THAT INHIBITS MELANIN BIOSYNTHESIS AND MELANOSOMAL TRANSFER.

HYPERPIGMENTATION IN HUMAN SOLAR LENTIGO IS PROMOTED BY HEPARANASE-INDUCED LOSS OF HEPARAN SULFATE CHAINS AT THE DERMAL–EPIDERMAL JUNCTION.

USE OF THE MATTEK EPI-100 IN VITRO SYSTEM TO SCREEN ANTIOXIDANT EFFICACY.

PREVALIDATION OF THE EPIDERM PHOTOTOXICITY TEST (ED-PT).

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