Reference Libraries

Cyclooxygenase-2 (COX-2) appears to play an important role in skin carcinogenesis caused by solar ultraviolet radiation (UVR): UVR induces COX-2 expression in human skin, COX-2 activity is upregulated in skin cancers and COX inhibitors reduce UVR-induced tumor formation. In this... Read More

Epidermal keratinocytes are exposed to a low water concentration at the stratum corneum stratum granulosum interface. When epithelial tissues are osmotically perturbed, cellular protection and cell volume regulation is mediated by accumulation of organic osmolytes such as taurine. Previous studies... Read More

EpiDerm™ is an in vitro organotypic human skin model cultured at the air/liquid interface to produce a three-dimensional tissue with a stratum corneum possessing a barrier function similar to native epidermis. The model is suitable for topical application of creams... Read More

Establishing an effective epidermal barrier requires a series of coordinated molecular events involving keratinocytes (KCs) within a stratified epithelium. Epidermal maturation depends on convergence of pathways involving components of NF-B and peroxisome proliferator activated receptor (PPAR) signaling systems that promote... Read More