Reference Libraries

December 11, 2015

DEVELOPMENT AND CHARACTERIZATION OF 3D PSORIATIC TISSUE MODEL.

Psoriasis is an inflammatory skin disease marked by hyperproliferation and abnormal keratinocyte differentiation that affects about 2% of the global population. In this study, we developed a human cell based in vitro psoriatic tissue model from psoriatic fibroblasts and normal... Read More

December 11, 2015

THE SERINE PROTEASE MARAPSIN IS EXPRESSED IN STRATIFIED SQUAMOUS EPITHELIA AND IS UP-REGULATED IN THE HYPERPROLIFERATIVE EPIDERMIS OF PSORIASIS AND REGENERATING WOUNDS.

The trypsin-like serine protease marapsin is a member of the large protease gene cluster at human chromosome 16p13.3, which also contains the structurally related proteases testisin, tryptase €, tryptase γ, and EOS. To gain insight into the biological functions of... Read More

December 11, 2015

HYPERPIGMENTATION IN HUMAN SOLAR LENTIGO IS PROMOTED BY HEPARANASE-INDUCED LOSS OF HEPARAN SULFATE CHAINS AT THE DERMAL–EPIDERMAL JUNCTION.

Background: Skin pigmentation induced by ultraviolet B radiation is caused in part by inflammation mediated by cytokines secreted from keratinocytes and fibroblasts in the irradiated area. Heparanase is also activated in the irradiated skin, and this leads to loss of... Read More

December 11, 2015

PREVALIDATION OF THE EPIDERM PHOTOTOXCITY TEST.

The EpiDerm™ phototoxicity test was chosen for prevalidation within ECVAM’s tiered prevalidation procedure, since production of the full human in vitro skin model Skin2™ had been ceased in October 1996. ZEBET had developed a test protocol of a Skin2 phototoxicity... Read More

December 11, 2015

AN ASSESSMENT OF THE PHOTOTOXIC HAZARD OF A PERSONAL PRODUCT INGREDIENT USING IN VITRO ASSAYS.

Where substances are intended for use in personal products applied to the skin an assessment of potential phototoxic hazard is required. This report describes a tiered testing strategy involving in vitro assays used for the phototoxic hazard assessment of a... Read More

Reference Libraries

DEVELOPMENT AND CHARACTERIZATION OF 3D PSORIATIC TISSUE MODEL.

THE SERINE PROTEASE MARAPSIN IS EXPRESSED IN STRATIFIED SQUAMOUS EPITHELIA AND IS UP-REGULATED IN THE HYPERPROLIFERATIVE EPIDERMIS OF PSORIASIS AND REGENERATING WOUNDS.

HYPERPIGMENTATION IN HUMAN SOLAR LENTIGO IS PROMOTED BY HEPARANASE-INDUCED LOSS OF HEPARAN SULFATE CHAINS AT THE DERMAL–EPIDERMAL JUNCTION.

PREVALIDATION OF THE EPIDERM PHOTOTOXCITY TEST.

AN ASSESSMENT OF THE PHOTOTOXIC HAZARD OF A PERSONAL PRODUCT INGREDIENT USING IN VITRO ASSAYS.

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