Reference Libraries

December 11, 2015

INITIAL CHARACTERIZATION OF AN EPIDERMAL MODEL CONTAINING FUNCTIONAL MELANOCYTES.

A model of the human epidermis, EpiDerm™, cultured from foreskin derived normal human epidermal keratinocytes (NHEK) has been shown to reproduce many of the histological and ultrastructural properties of native epidermis. In an effort to extend the utility and complexity... Read More

December 11, 2015

ECVAM FEASIBILITY STUDY: CAN THE PRE-VALIDATED IN VITRO SKIN MODEL PHOTOTOXICITY ASSAY BE UPGRADED TO QUANTIFY PHOTOTOXIC POTENCY OF TOPICAL PHOTOTOXINS?

This study by scientists at ZEBET (Germany) and the Czech Republic National Institute of Public Health (SZU) demonstrated that MatTek’s EpiDerm in vitro human skin tissue equivalent can be used in place of animals to accurately predict the phototoxicity of... Read More

December 11, 2015

CHANGES IN CANCER-RELATED GENE EXPRESSION IN AN IN VITRO HUMAN SKIN MODEL FOLLOWING UVB-IRRADIATION.

UV-irradiation causes initiation and promotion of skin cancers, photoaging and immunosuppression. To further our understanding of these processes at the molecular level, we utilized cDNA array technology to examine changes in gene expression in the EpiDerm™ in vitro human skin... Read More

December 11, 2015

NEW RESULTS WITH MELANODERM™, AN EPIDERMAL MODEL CONTAINING FUNCTIONAL MELANOCYTES.

We have previously reported on the successful incorporation of normal human melanocytes (NHM) into a highly differentiated, three-dimensional tissue culture model of human epidermis (JID, 104(4), 616, 1995). Melanocytes exhibited dendritic morphology, were localized in the basal cell layer, and... Read More

December 11, 2015

AN ASSESSMENT OF THE PHOTOTOXIC HAZARD OF A PERSONAL PRODUCT INGREDIENT USING IN VITRO ASSAYS.

Where substances are intended for use in personal products applied to the skin an assessment of potential phototoxic hazard is required. This report describes a tiered testing strategy involving in vitro assays used for the phototoxic hazard assessment of a... Read More

Reference Libraries

INITIAL CHARACTERIZATION OF AN EPIDERMAL MODEL CONTAINING FUNCTIONAL MELANOCYTES.

ECVAM FEASIBILITY STUDY: CAN THE PRE-VALIDATED IN VITRO SKIN MODEL PHOTOTOXICITY ASSAY BE UPGRADED TO QUANTIFY PHOTOTOXIC POTENCY OF TOPICAL PHOTOTOXINS?

CHANGES IN CANCER-RELATED GENE EXPRESSION IN AN IN VITRO HUMAN SKIN MODEL FOLLOWING UVB-IRRADIATION.

NEW RESULTS WITH MELANODERM™, AN EPIDERMAL MODEL CONTAINING FUNCTIONAL MELANOCYTES.

AN ASSESSMENT OF THE PHOTOTOXIC HAZARD OF A PERSONAL PRODUCT INGREDIENT USING IN VITRO ASSAYS.

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