Reference Libraries

June 16, 2023

Reconstructed human intestinal comet assay, a possible alternative in vitro model for genotoxicity assessment

The aim of the present study was to evaluate the compatibility of reconstructed 3D human small intestinal microtissues to perform the in vitro comet assay. The comet assay is a common follow-up genotoxicity test to confirm or supplement other genotoxicity... Read More

June 16, 2023

Use of In Vitro Human Skin Models to Assess Potential Immune Activation In Response to Biotherapeutic Attributes and Process-related Impurities

Subcutaneous (SubQ) injection is a common administration route for biotherapeutics. However, limited tools are available for understanding the dynamic relationships between drug products and resident cells following injection. Advances in tissue engineering have enabled the production of in vitro skin... Read More

June 13, 2023

Development of a micronucleus test using the EpiAirway™ organotypic human airway model

The use of organotypic human tissue models in genotoxicity has increased as an alternative to animal testing. Genotoxicity is generally examined using a battery of in vitro assays such as Ames and micronucleus (MN) tests that cover gene mutations and... Read More

June 13, 2023

Single-cell analysis of Kaposi’s sarcoma-associated herpesvirus infection in three-dimensional air-liquid interface culture model

The oral cavity is the major site for transmission of Kaposi’s sarcoma-associated herpesvirus (KSHV), but how KSHV establishes infection and replication in the oral epithelia remains unclear. Here, we report a KSHV spontaneous lytic replication model using fully differentiated, three... Read More

April 7, 2023

Bioengineering of Novel Organotypic 3D Human Liver/Hepatocyte Tissue Model for Drug Induced Liver Injury/Toxicity Studies

Development of a human primary cell-based 3D organotypic liver/hepatocyte tissue model with polarized hepatic morphology that maintains high level expression of major liver associated drug metabolizing enzymes is an attractive alternative platform to study acute and chronic liver toxicity and drug induced... Read More