Reference Libraries

December 11, 2015

USE OF NORMAL HUMAN 3D (NHU-3D) TISSUE MODELS (EPIDERM™, EPIAIRWAY™) FOR NANOTOXICOLOGY APPLICATIONS

Nanomaterials are increasingly utilized in numerous commercial applications where dermal contact, inhalation, or oral ingestion is likely. However, their toxicological properties are largely unknown. Potential adverse effects of nanoparticle exposure include allergenicity, cytotoxicity, and genotoxicity. Nanomaterials may enter the body... Read More

December 11, 2015

EVALUATION OF TISSUE ENGINEERED MODELS OF THE ORAL MUCOSA TO INVESTIGATE ORAL CANDIDIASIS.

Candida albicans is a commensal organism that can be isolated from the majority of healthy individuals. However, in certain susceptible individuals C. albicans can become pathogenic leading to the mucocutaneous infection; oral candidiasis. Murine models and in vitro monolayer cultures... Read More

December 11, 2015

IN VITRO ASSESSMENT OF PERSONAL CARE PRODUCTS FOR VAGINAL IRRITATION USING 3D TISSUE CONSTRUCTS.

Three dimensional (3D) human vaginal-ectocervical tissue constructs may be a relevant in vitro model to rapidly screen for vaginal mucosal irritation potential of raw materials and final formulations. Here we report results from a study with an in vitro vaginal... Read More

December 11, 2015

IDENTIFICATION OF TIGHT JUNCTION MODULATING LIPIDS.

Tight junctions (TJs) play an important role in regulating paracellular drug transport. The aim of this study was to identify lipids that rapidly and reversibly alter transepithelial electrical resistance (TER) and/or TJ permeability in epithelial tissue. In this study, we... Read More

December 11, 2015

ENGINEERING A DEGRADABLE POLYURETHANE INTRAVAGINAL RING FOR SUSTAINED DELIVERY OF DAPIVIRINE

We describe the engineering of a degradable intravaginal ring (IVR) for the delivery of the potent HIV-1 reverse transcriptase inhibitor dapivirine. The degradable polymer used in fabricating the device incorporated poly(caprolactone) ester blocks in a poly(tetramethylene ether) glycol ABA type... Read More

Reference Libraries

USE OF NORMAL HUMAN 3D (NHU-3D) TISSUE MODELS (EPIDERM™, EPIAIRWAY™) FOR NANOTOXICOLOGY APPLICATIONS

EVALUATION OF TISSUE ENGINEERED MODELS OF THE ORAL MUCOSA TO INVESTIGATE ORAL CANDIDIASIS.

IN VITRO ASSESSMENT OF PERSONAL CARE PRODUCTS FOR VAGINAL IRRITATION USING 3D TISSUE CONSTRUCTS.

IDENTIFICATION OF TIGHT JUNCTION MODULATING LIPIDS.

ENGINEERING A DEGRADABLE POLYURETHANE INTRAVAGINAL RING FOR SUSTAINED DELIVERY OF DAPIVIRINE

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