Reference Libraries

December 11, 2015

ORGANOTYPIC HUMAN VAGINAL-ECTOCERVICAL TISSUE MODEL FOR IRRITATION STUDIES OF SPERMICIDES, MICROBICIDES, AND FEMININE-CARE PRODUCTS.

This study by scientists at Boston University School of Medicine and MatTek Corp. demonstrated that MatTek’s EpiVaginal in vitro human cervico-vaginal tissue equivalent is a highly reproducible, non-animal means to assess the irritation potential of topically applied contraceptives, microbicides and... Read More

December 11, 2015

SAFETY TESTING OF SILICONE ELASTOMER MATRIX VAGINAL RINGS CONTAINING UC781 AND TWEEN 80 USING EPIVAGINAL(VEC-606) TISSUES.

The microbicidal agent UC781 has very limited aqueous solubility. A recent study in pig-tailed macaques showed poor pharmacokinetic levels, suggesting that, unlike in vitro release testing which uses relatively large volumes of a hydroalcoholic release media, the vaginal environment does... Read More

December 11, 2015

ENGINEERING A DEGRADABLE POLYURETHANE INTRAVAGINAL RING FOR SUSTAINED DELIVERY OF DAPIVIRINE

We describe the engineering of a degradable intravaginal ring (IVR) for the delivery of the potent HIV-1 reverse transcriptase inhibitor dapivirine. The degradable polymer used in fabricating the device incorporated poly(caprolactone) ester blocks in a poly(tetramethylene ether) glycol ABA type... Read More

December 11, 2015

IDENTIFICATION OF TIGHT JUNCTION MODULATING LIPIDS.

Tight junctions (TJs) play an important role in regulating paracellular drug transport. The aim of this study was to identify lipids that rapidly and reversibly alter transepithelial electrical resistance (TER) and/or TJ permeability in epithelial tissue. In this study, we... Read More

December 11, 2015

RECONSTRUCTION OF VAGINAL TISSUE MODEL FOR HIV INFECTION.

The HIV/AIDS epidemic is continuing to escalate worldwide and it is estimated that through the year 2000, more than 34 million people have already been infected with the virus. Daily, 16,000 individuals acquire HIV-1 infection and the majority of all... Read More

Reference Libraries

ORGANOTYPIC HUMAN VAGINAL-ECTOCERVICAL TISSUE MODEL FOR IRRITATION STUDIES OF SPERMICIDES, MICROBICIDES, AND FEMININE-CARE PRODUCTS.

SAFETY TESTING OF SILICONE ELASTOMER MATRIX VAGINAL RINGS CONTAINING UC781 AND TWEEN 80 USING EPIVAGINAL(VEC-606) TISSUES.

ENGINEERING A DEGRADABLE POLYURETHANE INTRAVAGINAL RING FOR SUSTAINED DELIVERY OF DAPIVIRINE

IDENTIFICATION OF TIGHT JUNCTION MODULATING LIPIDS.

RECONSTRUCTION OF VAGINAL TISSUE MODEL FOR HIV INFECTION.

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