Reference Libraries

December 11, 2015

IDENTIFICATION OF TIGHT JUNCTION MODULATING LIPIDS.

Tight junctions (TJs) play an important role in regulating paracellular drug transport. The aim of this study was to identify lipids that rapidly and reversibly alter transepithelial electrical resistance (TER) and/or TJ permeability in epithelial tissue. In this study, we... Read More

December 11, 2015

STUDIES ON VAGINAL INNATE IMMUNITY IN THE EPIVAGINAL MODEL.

This study by researchers at Boston University School of Medicine and MatTek Corp. demonstrated that the EpiVaginal full thickness human cervico-vaginal tissue equivalent can provide valuable information on molecular mechanisms of vaginal innate immunity, and serve as a test system... Read More

December 11, 2015

NAD(P)H:QUINONE REDUCTASE ACTIVITY IN HUMAN EPIDERMAL KERATINOCYTES AND RECONSTRUCTED EPIDERMAL MODELS.

Reconstructed epidermal models may provide a suitable and relevant model for screening compounds such as quinones, which affect the activities of phase I and II enzymes involved in epidermal detoxification. Reconstructed epidermis may also allow the study of the metabolism... Read More

December 11, 2015

AN IN VITRO MODEL OF HUMAN AIRWAY EPITHELIUM (EPIAIRWAY) FOR IN VITRO METABOLISM, TOXICITY SCREENING AND DRUG DELIVERY APPLICATIONS.

This study by MatTek Corp. scientists demonstrated that the EpiAirway in vitro human tracheal/bronchial tissue equivalent possesses the in vivo-like physical and biochemical attributes necessary for evaluating the delivery of drugs, metabolism, airway irritation, and toxicity potential of environmental/occupational chemicals.... Read More

December 11, 2015

HUMAN VAGINAL-ECTOCERVICAL TISSUE MODEL FOR MICROBICIDE IRRITATION STUDIES.

Infection through the vaginal-ectocervical (VEC) tissue is believed to be the main route for the heterosexual transmission of the human immunodeficiency virus (HIV) in women. Recently, a tissue culture-based model of the VEC (EpiVaginal) has been developed. Normal, human VEC... Read More

Reference Libraries

IDENTIFICATION OF TIGHT JUNCTION MODULATING LIPIDS.

STUDIES ON VAGINAL INNATE IMMUNITY IN THE EPIVAGINAL MODEL.

NAD(P)H:QUINONE REDUCTASE ACTIVITY IN HUMAN EPIDERMAL KERATINOCYTES AND RECONSTRUCTED EPIDERMAL MODELS.

AN IN VITRO MODEL OF HUMAN AIRWAY EPITHELIUM (EPIAIRWAY) FOR IN VITRO METABOLISM, TOXICITY SCREENING AND DRUG DELIVERY APPLICATIONS.

HUMAN VAGINAL-ECTOCERVICAL TISSUE MODEL FOR MICROBICIDE IRRITATION STUDIES.

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