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December 11, 2015

IN VITRO ASSESSMENT OF PERSONAL CARE PRODUCTS FOR VAGINAL IRRITATION USING 3D TISSUE CONSTRUCTS.

Three dimensional (3D) human vaginal-ectocervical tissue constructs may be a relevant in vitro model to rapidly screen for vaginal mucosal irritation potential of raw materials and final formulations. Here we report results from a study with an in vitro vaginal... Read More

December 11, 2015

ORGANOTYPIC HUMAN VAGINAL-ECTOCERVICAL TISSUE MODEL FOR IRRITATION STUDIES OF SPERMICIDES, MICROBICIDES, AND FEMININE-CARE PRODUCTS.

This study by scientists at Boston University School of Medicine and MatTek Corp. demonstrated that MatTek’s EpiVaginal in vitro human cervico-vaginal tissue equivalent is a highly reproducible, non-animal means to assess the irritation potential of topically applied contraceptives, microbicides and... Read More

December 11, 2015

IDENTIFICATION OF TIGHT JUNCTION MODULATING LIPIDS.

Tight junctions (TJs) play an important role in regulating paracellular drug transport. The aim of this study was to identify lipids that rapidly and reversibly alter transepithelial electrical resistance (TER) and/or TJ permeability in epithelial tissue. In this study, we... Read More

December 11, 2015

ENGINEERING A DEGRADABLE POLYURETHANE INTRAVAGINAL RING FOR SUSTAINED DELIVERY OF DAPIVIRINE

We describe the engineering of a degradable intravaginal ring (IVR) for the delivery of the potent HIV-1 reverse transcriptase inhibitor dapivirine. The degradable polymer used in fabricating the device incorporated poly(caprolactone) ester blocks in a poly(tetramethylene ether) glycol ABA type... Read More

December 11, 2015

STUDIES ON VAGINAL INNATE IMMUNITY IN THE EPIVAGINAL MODEL.

This study by researchers at Boston University School of Medicine and MatTek Corp. demonstrated that the EpiVaginal full thickness human cervico-vaginal tissue equivalent can provide valuable information on molecular mechanisms of vaginal innate immunity, and serve as a test system... Read More

Reference Libraries

IN VITRO ASSESSMENT OF PERSONAL CARE PRODUCTS FOR VAGINAL IRRITATION USING 3D TISSUE CONSTRUCTS.

ORGANOTYPIC HUMAN VAGINAL-ECTOCERVICAL TISSUE MODEL FOR IRRITATION STUDIES OF SPERMICIDES, MICROBICIDES, AND FEMININE-CARE PRODUCTS.

IDENTIFICATION OF TIGHT JUNCTION MODULATING LIPIDS.

ENGINEERING A DEGRADABLE POLYURETHANE INTRAVAGINAL RING FOR SUSTAINED DELIVERY OF DAPIVIRINE

STUDIES ON VAGINAL INNATE IMMUNITY IN THE EPIVAGINAL MODEL.

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