December 11, 2015
Reference Libraries
December 11, 2015
OPTIMISATION OF THE EPIDERM TEST PROTOCOL FOR THE UPCOMING ECVAM VALIDATION STUDY ON IN VITRO SKIN IRRITATION TESTS.
*An ECVAM-funded prevalidation study (PV) was conducted during 1999 and 2000 to identify in vitro tests capable of reliably distinguishing between skin irritants (I) and non-irritants(NI) according to European Union risk phrases (“R38” or no classification). The tests evaluated were... Read More
December 11, 2015
HUMAN VAGINAL-ECTOCERVICAL TISSUE MODEL FOR MICROBICIDE IRRITATION STUDIES.
Infection through the vaginal-ectocervical (VEC) tissue is believed to be the main route for the heterosexual transmission of the human immunodeficiency virus (HIV) in women. Recently, a tissue culture-based model of the VEC (EpiVaginal) has been developed. Normal, human VEC... Read More
December 11, 2015
INHIBITION OF CRYSTALLIZATION IN DRUG-IN-ADHESIVE-TYPE TRANSDERMAL PATCHES.
In this study the ability of various additives to inhibit crystallization of two model drugs, captopril and levonorgestrel, in acrylate and silicone adhesives was investigated. Among the various additives tested, PVP was found to be the most effective in inhibiting... Read More
December 11, 2015
IN VITRO SAFETY PROFILE OF PERSONAL CARE PRODUCTS – USE OF AN IN VITRO TESTING PLATFORM BASED ON A RECONSTRUCTED VAGINAL TISSUE MODEL
One of the common goals of industry is to confirm the safety of their products. Ethical concerns have led to the use of alternative testing methods in lieu of traditional testing methods. Several studies have shown good correlation between alternative... Read More
