Reference Libraries

December 11, 2015

GENOTOXICITY TESTING USING THE MICRONUCLEUS ASSAY IN THE EPIDERM™ HUMAN 3D SKIN MODEL.

This study by scientists at Procter & Gamble, the Institute for In Vitro Sciences (IIVS), and MatTek Corp. demonstrated that the Micronucleus Assay that utilizes MatTek’s EpiDerm in vitro human skin tissue equivalent with inherent metabolic activity holds excellent promise... Read More

December 11, 2015

INVESTIGATION OF THE BIOTRANSFORMING CAPACITY OF HUMAN RECONSTRUCTED SKIN MODELS FOR GENOTOXICITY TESTING.

Skin penetration is a route of xenobiotic uptake in the body, however, less information is available about the fate of the penetrated xenobiotic in regard of metabolic turn over. The presence of xenobiotic metabolizing enzymes in skin has previously been... Read More

December 11, 2015

DNA DOUBLE-STRAND BREAKS FORM IN BYSTANDER CELLS AFTER MICROBEAM IRRADIATION OF THREE-DIMENSIONAL HUMAN TISSUE MODELS.

This study by researchers at the National Cancer Institute (NIH), University of Lethbridge (Canada) and Columbia University demonstrated the ability to use MatTek’s EpiDermFT and EpiAirway in vitro human tissue equivalents as accurate in vitro surrogates to study phenomena known... Read More

December 11, 2015

FURTHER DEVELOPMENT OF THE EPIDERM 3D RECONSTRUCTED HUMAN SKIN MICRONUCLEUS (RSMN) ASSAY.

This study by scientists at Procter & Gamble Co., the Institute for In Vitro Sciences (IIVS), Advanced Testing Laboratory and MatTek Corp. demonstrated that an in vitro human reconstructed skin micronucleus assay (RSMN) based on MatTek’s EpiDerm in vitro human... Read More

December 11, 2015

METABOLICALLY COMPETENT HUMAN SKIN MODELS: ACTIVATION AND GENOTOXICITY OF BENZO[A]PYRENE.

The polycyclic aromatic hydrocarbon (PAH) benzo[a]pyrene (BP) is metabolized into a complex pattern of BP derivatives, among which the ultimate carcinogen (+)-anti-BP-7,8-diol-9,10- epoxide (BPDE) is formed to certain extents. Skin is frequently in contact with PAHs and data on the... Read More

Reference Libraries

GENOTOXICITY TESTING USING THE MICRONUCLEUS ASSAY IN THE EPIDERM™ HUMAN 3D SKIN MODEL.

INVESTIGATION OF THE BIOTRANSFORMING CAPACITY OF HUMAN RECONSTRUCTED SKIN MODELS FOR GENOTOXICITY TESTING.

DNA DOUBLE-STRAND BREAKS FORM IN BYSTANDER CELLS AFTER MICROBEAM IRRADIATION OF THREE-DIMENSIONAL HUMAN TISSUE MODELS.

FURTHER DEVELOPMENT OF THE EPIDERM 3D RECONSTRUCTED HUMAN SKIN MICRONUCLEUS (RSMN) ASSAY.

METABOLICALLY COMPETENT HUMAN SKIN MODELS: ACTIVATION AND GENOTOXICITY OF BENZO[A]PYRENE.

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