Reference Libraries

December 11, 2015

THE USE OF HUMAN 3D EPIDERMAL MODELS FOR GENOTOXICITY TESTING: RESULTS WITH THE COMET ASSAY.

EU policy, including REACH and the Cosmetics Directive, implies the urgent need for reliable in vitro strategies with regards to the safety evaluation of chemicals. Currently used in vitro assays are not sufficiently suitable to reliably evaluate substances, for example... Read More

December 11, 2015

METABOLICALLY COMPETENT HUMAN SKIN MODELS: ACTIVATION AND GENOTOXICITY OF BENZO[A]PYRENE.

The polycyclic aromatic hydrocarbon (PAH) benzo[a]pyrene (BP) is metabolized into a complex pattern of BP derivatives, among which the ultimate carcinogen (+)-anti-BP-7,8-diol-9,10- epoxide (BPDE) is formed to certain extents. Skin is frequently in contact with PAHs and data on the... Read More

December 11, 2015

GENOTOXICITY TESTING USING THE MICRONUCLEUS ASSAY IN THE EPIDERM™ HUMAN 3D SKIN MODEL.

This study by scientists at Procter & Gamble, the Institute for In Vitro Sciences (IIVS), and MatTek Corp. demonstrated that the Micronucleus Assay that utilizes MatTek’s EpiDerm in vitro human skin tissue equivalent with inherent metabolic activity holds excellent promise... Read More

December 11, 2015

FURTHER DEVELOPMENT OF THE EPIDERM 3D RECONSTRUCTED HUMAN SKIN MICRONUCLEUS (RSMN) ASSAY.

This study by scientists at Procter & Gamble Co., the Institute for In Vitro Sciences (IIVS), Advanced Testing Laboratory and MatTek Corp. demonstrated that an in vitro human reconstructed skin micronucleus assay (RSMN) based on MatTek’s EpiDerm in vitro human... Read More

December 11, 2015

Reference Libraries

THE USE OF HUMAN 3D EPIDERMAL MODELS FOR GENOTOXICITY TESTING: RESULTS WITH THE COMET ASSAY.

METABOLICALLY COMPETENT HUMAN SKIN MODELS: ACTIVATION AND GENOTOXICITY OF BENZO[A]PYRENE.

GENOTOXICITY TESTING USING THE MICRONUCLEUS ASSAY IN THE EPIDERM™ HUMAN 3D SKIN MODEL.

FURTHER DEVELOPMENT OF THE EPIDERM 3D RECONSTRUCTED HUMAN SKIN MICRONUCLEUS (RSMN) ASSAY.

INTRALABORATORY AND INTERLABORATORY EVALUATION OF THE EPIDERM 3D HUMAN RECONSTRUCTED SKIN MICRONUCLEUS (RSMN) ASSAY.

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