Reference Libraries

December 11, 2015

METABOLICALLY COMPETENT HUMAN SKIN MODELS: ACTIVATION AND GENOTOXICITY OF BENZO[A]PYRENE.

The polycyclic aromatic hydrocarbon (PAH) benzo[a]pyrene (BP) is metabolized into a complex pattern of BP derivatives, among which the ultimate carcinogen (+)-anti-BP-7,8-diol-9,10- epoxide (BPDE) is formed to certain extents. Skin is frequently in contact with PAHs and data on the... Read More

December 11, 2015

USE OF THE COMET ASSAY TO DETECT GENOTOXIC EFFECTS IN RECONSTITUTED HUMAN SKIN.

This study by scientists at Procter & Gamble and Wella-Cosmital SA demonstrated that MatTek’s EpiDerm in vitro human tissue equivalent may provide an excellent platform for performing comet (genotoxicity) assays of dermally applied cosmetics and their constituents because EpiDerm is... Read More

December 11, 2015

SYSTEMATIC IDENTIFICATION OF PROTEASES AND ANTI-PROTEASES IN DEVELOPING PRIMARY AIRWAY EPITHELIAL CELLS BY GLOBAL GENE EXPRESSION.

This study by researchers at Oxford University demonstrated that the genomics of human epithelial tissue development and differentiation can be investigated using standard global gene expression analysis techniques and MatTek’s in vitro human tissue equivalents, in this case EpiAirway in... Read More

December 11, 2015

PROTECTING THE SKIN AGAINST OZONE.

This study by researchers at Arch Personal Care Products and Bioinnovation Laboratories demonstrated that MatTek’s EpiDerm and MelanoDerm in vitro human skin tissue equivalents could be used to prove that topical application of ozone stressed yeast extract protected the EpiDerm... Read More

December 11, 2015

XENOBIOTIC METABOLIZING CAPABILITIES OF THE EPIDERM IN VITRO HUMAN SKIN EQUIVALENT.

This study by scientists at Procter and Gamble, the Institute for In Vitro Sciences (IIVS), and MatTek Corp. demonstrated that MatTek’s EpiDerm in vitro human skin tissue equivalent possesses numerous in vivo-like Xenobiotic Metabolizing Enzyme (XME) activities and is therefore... Read More

Reference Libraries

METABOLICALLY COMPETENT HUMAN SKIN MODELS: ACTIVATION AND GENOTOXICITY OF BENZO[A]PYRENE.

USE OF THE COMET ASSAY TO DETECT GENOTOXIC EFFECTS IN RECONSTITUTED HUMAN SKIN.

SYSTEMATIC IDENTIFICATION OF PROTEASES AND ANTI-PROTEASES IN DEVELOPING PRIMARY AIRWAY EPITHELIAL CELLS BY GLOBAL GENE EXPRESSION.

PROTECTING THE SKIN AGAINST OZONE.

XENOBIOTIC METABOLIZING CAPABILITIES OF THE EPIDERM IN VITRO HUMAN SKIN EQUIVALENT.

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