Reference Libraries

December 11, 2015

INVESTIGATION OF THE BIOTRANSFORMING CAPACITY OF HUMAN RECONSTRUCTED SKIN MODELS FOR GENOTOXICITY TESTING.

Skin penetration is a route of xenobiotic uptake in the body, however, less information is available about the fate of the penetrated xenobiotic in regard of metabolic turn over. The presence of xenobiotic metabolizing enzymes in skin has previously been... Read More

December 11, 2015

IMPROVING GENOTOXICITY TESTING: COMET ASSAY WITH 3D SKIN MODELS.

This study by scientists at Henkel, ECVAM, TNO, L’Oreal, COLIPA, Procter and Gamble – Cosmital SA, Unilever, Procter and Gamble US, Beiersdorf, KPSS (Kao Professional Salon Services), GlaxoSmithKline (GSK) and Pierre Fabre demonstrated that MatTek’s EpiDerm in vitro 3-D human... Read More

December 11, 2015

ASSESSMENT OF AIRWAY GENOTOXICITY POTENTIAL USING THE EPIAIRWAY IN VITRO HUMAN AIRWAY MODEL AND THE COMET ASSAY.

Determination of genotoxic potential is an important consideration for safety assessment of chemicals that may be inhaled following exposure to consumer products, occupational chemicals or environmental pollutants. Commonly used in vitro genotoxicity assays produce a high rate of false positive... Read More

December 11, 2015

GENOTOXICITY TESTING USING THE NORMAL HUMAN CELL BASED 3D EPITHELIAL MODELS.

Safety assessment of new products for human use requires genotoxicity testing to ensure their non-carcinogenicity. Current in vitro genotoxicity assays have low specificity resulting in unacceptably high rates of false positives. Moreover, starting in 2009, in vivo genotoxicity testing was... Read More

December 11, 2015

GENE EXPRESSION PROFILE OF TISSUE ENGINEERED SKIN SUBJECTED TO ACUTE BARRIER DISRUPTION.

The main function of the skin is to protect the body from infection, dehydration, and other environmental insults by creating an impermeable barrier of cornified cell layers, the stratum corneum. In contrast to cells in culture, tissue-engineeried skin equivalents contain... Read More

Reference Libraries

INVESTIGATION OF THE BIOTRANSFORMING CAPACITY OF HUMAN RECONSTRUCTED SKIN MODELS FOR GENOTOXICITY TESTING.

IMPROVING GENOTOXICITY TESTING: COMET ASSAY WITH 3D SKIN MODELS.

ASSESSMENT OF AIRWAY GENOTOXICITY POTENTIAL USING THE EPIAIRWAY IN VITRO HUMAN AIRWAY MODEL AND THE COMET ASSAY.

GENOTOXICITY TESTING USING THE NORMAL HUMAN CELL BASED 3D EPITHELIAL MODELS.

GENE EXPRESSION PROFILE OF TISSUE ENGINEERED SKIN SUBJECTED TO ACUTE BARRIER DISRUPTION.

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