Reference Libraries

December 11, 2015

The Cosmetics Europe strategy for animal-free genotoxicity testing: project status up-date

The Cosmetics Europe (formerly COLIPA) Genotoxicity Task Force has driven and funded three projects to help address the high rate of misleading positives in in vitro genotoxicity tests: The completed “False Positives” project optimized current mammalian cell assays and showed... Read More

December 11, 2015

ANALYSIS OF GLOBAL GENE EXPRESSION PROFILE CHANGES DURING THE DIFFERENTIATION OF THE EPIDERM™ IN VITRO HUMAN SKIN EQUIVALENT.

This study by researchers at Oxford University’s Wellcome Trust Centre for Human Genetics and the Oxford Centre for Gene Function demonstrated how MatTek’s EpiDerm in vitro human skin tissue equivalent can be used to provide a working knowledge of normal... Read More

December 11, 2015

XENOBIOTIC METABOLIZING CAPABILITIES OF THE EPIDERM IN VITRO HUMAN SKIN EQUIVALENT.

This study by scientists at Procter and Gamble, the Institute for In Vitro Sciences (IIVS), and MatTek Corp. demonstrated that MatTek’s EpiDerm in vitro human skin tissue equivalent possesses numerous in vivo-like Xenobiotic Metabolizing Enzyme (XME) activities and is therefore... Read More

December 11, 2015

PROTECTING THE SKIN AGAINST OZONE.

This study by researchers at Arch Personal Care Products and Bioinnovation Laboratories demonstrated that MatTek’s EpiDerm and MelanoDerm in vitro human skin tissue equivalents could be used to prove that topical application of ozone stressed yeast extract protected the EpiDerm... Read More

December 11, 2015

GENOTOXICITY TESTING USING THE NORMAL HUMAN CELL BASED 3D EPITHELIAL MODELS.

Safety assessment of new products for human use requires genotoxicity testing to ensure their non-carcinogenicity. Current in vitro genotoxicity assays have low specificity resulting in unacceptably high rates of false positives. Moreover, starting in 2009, in vivo genotoxicity testing was... Read More

Reference Libraries

The Cosmetics Europe strategy for animal-free genotoxicity testing: project status up-date

ANALYSIS OF GLOBAL GENE EXPRESSION PROFILE CHANGES DURING THE DIFFERENTIATION OF THE EPIDERM™ IN VITRO HUMAN SKIN EQUIVALENT.

XENOBIOTIC METABOLIZING CAPABILITIES OF THE EPIDERM IN VITRO HUMAN SKIN EQUIVALENT.

PROTECTING THE SKIN AGAINST OZONE.

GENOTOXICITY TESTING USING THE NORMAL HUMAN CELL BASED 3D EPITHELIAL MODELS.

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