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December 11, 2015

CYTOKINE GENE EXPRESSION IN THE MATTEK EPIDERM CULTURES.

Human skin equivalent cultures are currently being investigated as in vitro models to predict the contact sensitization potential of chemicals. The objective of the research presented here is to evaluate the constitutive expression of a panel of immunomodulatory cytokine genes... Read More

December 11, 2015

XENOBIOTIC METABOLIZING CAPABILITIES OF THE EPIDERM IN VITRO HUMAN SKIN EQUIVALENT.

This study by scientists at Procter and Gamble, the Institute for In Vitro Sciences (IIVS), and MatTek Corp. demonstrated that MatTek’s EpiDerm in vitro human skin tissue equivalent possesses numerous in vivo-like Xenobiotic Metabolizing Enzyme (XME) activities and is therefore... Read More

December 11, 2015

THE EYE IRRITATION TESTING OF THE ORGANIC SOLVENTS ON IN VITRO TEST USING 3-D CORNEAL MODEL.

It has been reported that many in vitro test alternatives to the Draise eye irritation testing (Draize test) are able to evaluate irritation due to surfactants, but not organic solvents. We therefore examined an in vitro test using a 3-D... Read More

December 11, 2015

FURTHER EVALUATION OF THE EPIDERM AND EPIOCULAR IN VITRO IRRITATION MODELS.

Both EpiDerm™ and EpiOcular™ commercially available in vitro models for assessing the skin and eye irritation potential, respectively, of chemicals. The EpiDerm and EpiOcular tissue models are organotypic three-dimensional human skin and corneal analogues derived from human epidermal keratinocytes. Both... Read More

December 11, 2015

THE EPIOCULAR PREDICTION MODEL: A REPRODUCIBLE IN VITRO MEANS OF ASSESSING OCULAR IRRITANCY POTENTIAL.

The EpiOcular™ tissue model (OCL-200) is an organotypic model of the human corneal epithelium (HCE) cultured from normal human keratinocytes using serum-free medium. Haematoxylin and Eosin stained histological sections show the structure of EpiOcular to closely parallel that of the... Read More

Reference Libraries

CYTOKINE GENE EXPRESSION IN THE MATTEK EPIDERM CULTURES.

XENOBIOTIC METABOLIZING CAPABILITIES OF THE EPIDERM IN VITRO HUMAN SKIN EQUIVALENT.

THE EYE IRRITATION TESTING OF THE ORGANIC SOLVENTS ON IN VITRO TEST USING 3-D CORNEAL MODEL.

FURTHER EVALUATION OF THE EPIDERM AND EPIOCULAR IN VITRO IRRITATION MODELS.

THE EPIOCULAR PREDICTION MODEL: A REPRODUCIBLE IN VITRO MEANS OF ASSESSING OCULAR IRRITANCY POTENTIAL.

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CYTOKINE GENE EXPRESSION IN THE MATTEK EPIDERM CULTURES.