Reference Libraries

April 7, 2023

Antiviral activity of EIDD-1931 and Remdesivir against SARS-CoV-2 variants in a 3D mucociliary tissue models consisting of normal human-derived tracheal/bronchial (EpiAirway) and nasal (EpiNasal) epithelial cells

In vitro assays are an important early step to determine the potential antiviral activity of novel compounds. The antiviral efficacy of compounds is often evaluated in immortalized cell lines, which offer the advantage of cost effectiveness, ease of use, and... Read More

February 10, 2023

Validation of physiologically relevant in vitro human inhalation toxicity tests for volatile liquids, mists, and sprays

In vivo animal models are currently accepted by regulatory authorities for acute respiratory toxicity (ART) testing. However, animal tests have been discredited as predictors of human responses on physiological and ethical grounds. The goal of this work was to develop... Read More

February 10, 2023

Safety assessment scheme for menstrual cups and application for the evaluation of a menstrual cup comprised of medical grade silicone

Background Ensuring menstrual cup safety is paramount, yet a menstrual cup safety assessment scheme is lacking. This paper presents a quadripartite scheme, showing how it can be applied. Methods The Tampax Menstrual Cup was evaluated in the safety assessment scheme:... Read More

February 9, 2023

Modeling of Ligand-Induced Acute and Chronic Inflammation in the gastrointestinal tract using In vitro 3D-human small intestinal microtissues

Intestinal epithelium is known to be involved in innate immune responses by recognizing potential pathogens through cellular pattern recognition receptors (PRRs). The purpose of this study is to investigate PRR responses following exposure of an in vitro 3D human small... Read More

January 13, 2023

Determination and Sub-categorization of Ocular Irritants Using the EpiOcular Tissue Model – Prediction Models for Liquids and Solids

Assessment of serious eye damage/eye irritation originally involved the use of laboratory animals (OECD TG 405). In 2015, a new test guideline (OECD TG 492) was accepted which enables the use of an in vitro procedure based on reconstructed human... Read More