Reference Libraries

December 11, 2015

XENOBIOTIC METABOLIZING CAPABILITIES OF THE EPIDERM IN VITRO HUMAN SKIN EQUIVALENT.

This study by scientists at Procter and Gamble, the Institute for In Vitro Sciences (IIVS), and MatTek Corp. demonstrated that MatTek’s EpiDerm in vitro human skin tissue equivalent possesses numerous in vivo-like Xenobiotic Metabolizing Enzyme (XME) activities and is therefore... Read More

December 11, 2015

EYE AND SKIN IRRITATION IN 3-D HUMAN TISSUE CONSTRUCTS USING MTT AND ATP ENDPOINTS.

This study by scientists at Beauty Avenues and the Institute for In Vitro Sciences (IIVS) demonstrated that MatTek’s EpiDerm in vitro 3-D human skin tissue equivalent and EpiOcular in vitro 3-D human corneal tissue equivalent can be used, if/when necessary,... Read More

December 11, 2015

ASSESSMENT OF AIRWAY GENOTOXICITY POTENTIAL USING THE EPIAIRWAY IN VITRO HUMAN AIRWAY MODEL AND THE COMET ASSAY.

Determination of genotoxic potential is an important consideration for safety assessment of chemicals that may be inhaled following exposure to consumer products, occupational chemicals or environmental pollutants. Commonly used in vitro genotoxicity assays produce a high rate of false positive... Read More

December 11, 2015

The Cosmetics Europe strategy for animal-free genotoxicity testing: project status up-date

The Cosmetics Europe (formerly COLIPA) Genotoxicity Task Force has driven and funded three projects to help address the high rate of misleading positives in in vitro genotoxicity tests: The completed “False Positives” project optimized current mammalian cell assays and showed... Read More

December 11, 2015

GENE EXPRESSION PROFILE OF TISSUE ENGINEERED SKIN SUBJECTED TO ACUTE BARRIER DISRUPTION.

The main function of the skin is to protect the body from infection, dehydration, and other environmental insults by creating an impermeable barrier of cornified cell layers, the stratum corneum. In contrast to cells in culture, tissue-engineeried skin equivalents contain... Read More

Reference Libraries

XENOBIOTIC METABOLIZING CAPABILITIES OF THE EPIDERM IN VITRO HUMAN SKIN EQUIVALENT.

EYE AND SKIN IRRITATION IN 3-D HUMAN TISSUE CONSTRUCTS USING MTT AND ATP ENDPOINTS.

ASSESSMENT OF AIRWAY GENOTOXICITY POTENTIAL USING THE EPIAIRWAY IN VITRO HUMAN AIRWAY MODEL AND THE COMET ASSAY.

The Cosmetics Europe strategy for animal-free genotoxicity testing: project status up-date

GENE EXPRESSION PROFILE OF TISSUE ENGINEERED SKIN SUBJECTED TO ACUTE BARRIER DISRUPTION.

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