Reference Libraries

The present project arose out of the proposals of a working group on reference standards established by ECVAM in 1997. The primary objective of this pilot study was to determine whether the current approach of using in vitro data to... Read More

The EpiOcular™ tissue model (OCL-200) is an organotypic model of the human corneal epithelium (HCE) cultured from normal human keratinocytes using serum free medium. Parafin embedded, H&E stained histology cross-sections show the structure of EpiOcular closely parallels that of the... Read More

The EpiOcular™ tissue model (OCL-200) is an organotypic model of the human corneal epithelium (HCE) cultured from normal human keratinocytes using serum-free medium. Haematoxylin and Eosin stained histological sections show the structure of EpiOcular to closely parallel that of the... Read More

It has been reported that many in vitro test alternatives to the Draise eye irritation testing (Draize test) are able to evaluate irritation due to surfactants, but not organic solvents. We therefore examined an in vitro test using a 3-D... Read More

Cosmetic ingredients were tested to determine the ability of the EpiOcular™ tissue model to predict eye irritation potential. In vitro results were compared with historical Draize eye irritation records. Forty-three samples, consisting of 40 cosmetic raw ingredients of different type... Read More