Reference Libraries

Evaluating ocular irritation of eye-area cosmetics is essential to their safety assessment. Although eye-area formulations are designed to be mild, subjective/objective ocular responses can limit their acceptability. This study evaluated two similar formulations by comparing alternative assays, selected for their... Read More

Information in the literature suggests that the most promising developments in in vitro ocular irritation assays are those involving 3-dimensional (3-D) models of the cornea1-5. In this study, the effects of materials of known ocular irritancy on two commercial models... Read More

EpiOcular™ (OCL-200) is an organotypic tissue model of the human corneal epithelium (HCE) cultured from normal human keratinocytes using serum free medium. H&E stained histological cross-sections show that the structure of EpiOcular closely parallels that of the human corneal epithelium.... Read More

The EpiOcular™ tissue model (OCL-200) is an organotypic model of the human corneal epithelium (HCE) cultured from normal human keratinocytes using serum-free medium. Haematoxylin and Eosin stained histological sections show the structure of EpiOcular to closely parallel that of the... Read More

Both EpiDerm™ and EpiOcular™ commercially available in vitro models for assessing the skin and eye irritation potential, respectively, of chemicals. The EpiDerm and EpiOcular tissue models are organotypic three-dimensional human skin and corneal analogues derived from human epidermal keratinocytes. Both... Read More