Reference Libraries

December 11, 2015

INITIAL CHARACTERIZATION OF A NEW MODEL FOR OCULAR IRRITANCY TESTING.

A three dimensional, tissue culture construct, EpiDerm-SCA (EpiOcular™), based on neonatal foreskin-derived normal human epidermal keratinocytes (NHEK) is under development by MatTek Corporation. Cultured using serum free media in easily handled Millicell® CM (Millipore Corp.) cell culture inserts, the model... Read More

December 11, 2015

UPDATE OF THE COLIPA EYE IRRITATION TASK FORCE STRATEGY AND PROGRAMME FOR DEVELOPMENT OF IN VITRO METHODS.

Colipa (European Cosmetics Association) is conducting an eye irritation programme for development of in vitro methods to replace the Draize rabbit eye test (now banned for evaluating cosmetic ingredients). This programme is focused on identification of new in vitro test... Read More

December 11, 2015

PROSPECTIVE VALIDATION STUDY OF RECONSTRUCTED HUMAN TISSUE MODELS FOR EYE IRRITATION TESTING.

ECVAM/Colipa RhT test methods prospective validation study: The objective of the Eye Irritation Validation Study (EIVS) is to formally evaluate the scientific validity of the SkinEthicTM Human Corneal Epithelium (HCE) Short Exposure (SE), Long Exposure (LE) and test strategy and... Read More

December 11, 2015

EURL ECVAM – Cosmetics Europe Prospective validation study of EpiOcular™ EIT & SkinEthic™ HCE

A prospective validation study of two Reconstructed human Tissuebased in vitro test methods (EpiOcular™ EIT and SkinEthic™ HCE) was conducted by EURL ECVAM and Cosmetics Europe to evaluate their usefulness to identify chemicals as either not classified for serious eye... Read More

December 11, 2015

MATTEK’S TISSUE MODELS: NEW DEVELOPMENTS.

MatTek commercially offers three organotypic tissue models for irritancy and mechanistic studies: 1) EpiDerm™, a highly differentiated, keratinocyte-only model of the epidermis, 2) MelanoDerm™, a second generation version of EpiDerm in which functioning melanocytes have been incorporated, and 3) EpiOcular™,... Read More

Reference Libraries

INITIAL CHARACTERIZATION OF A NEW MODEL FOR OCULAR IRRITANCY TESTING.

UPDATE OF THE COLIPA EYE IRRITATION TASK FORCE STRATEGY AND PROGRAMME FOR DEVELOPMENT OF IN VITRO METHODS.

PROSPECTIVE VALIDATION STUDY OF RECONSTRUCTED HUMAN TISSUE MODELS FOR EYE IRRITATION TESTING.

EURL ECVAM – Cosmetics Europe Prospective validation study of EpiOcular™ EIT & SkinEthic™ HCE

MATTEK’S TISSUE MODELS: NEW DEVELOPMENTS.

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