Reference Libraries

August 15, 2022

p38 MAP Kinase Inhibition Reduces Propionibacterium acnes-Induced Inflammation in Vitro

Introduction: Propionibacterium acnes, a ubiquitous skin bacterium, stimulates keratinocytes to produce a number of proinflammatory cytokines and may contribute to inflammatory acne. The aim of the study was to investigate whether P. acnesinduced proinflammatory cytokine release is mediated by P.... Read More

July 20, 2022

Regeneration of collagen fibrils at the papillary dermis by reconstructing basement membrane at the dermal–epidermal junction

The epidermal basement membrane deteriorates with aging. We previously reported that basementmembrane reconstruction not only serves to maintain epidermal stem/progenitor cells in the epidermis, but also increases collagen fibrils in the papillary dermis. Here, we investigated the mechanism of the... Read More

July 18, 2022

Characterization of application scenario-dependent pharmacokinetics and pharmacodynamic properties of permethrin and hyperforin in a dynamic skin and liver multi-organ-chip model

Microphysiological systems (MPS) aim to mimic the dynamic microenvironment and the interaction between tissues. While MPS exist for investigating pharmaceuticals, the applicability of MPS for cosmetics ingredients is yet to be evaluated. The HUMIMIC Chip2 (“Chip2′′ ), is the first... Read More

July 13, 2022

Anti-aging Effects of Retinoid Hydroxypinacolone Retinoate on Skin Models

Tretinoin, also known as all-trans retinoic acid (ATRA), has been well-known for its anti-aging effects on skin since the 1980s.1,2 ATRA functions by activating the nuclear retinoic acid family of receptors (RARs), which control gene transcription by binding to retinoic... Read More