Reference Libraries

October 7, 2022

Protective effects of a comprehensive topical antioxidant against ozone‑induced damage in a reconstructed human skin model

Tropospheric ozone (O3) is a source of oxidative stress. This study examined the ability of a topical antioxidant (WEL-DS) to inhibit O3-mediated damage in a human epidermal skin model. Four groups of tissues (N = 24) were compared: Group 1... Read More

September 16, 2022

Investigating the sonophoresis effect on the permeation of diclofenac sodium using 3D skin equivalent

Ultrasound temporally increases skin permeability by altering stratum corneum SC function (sonophoresis). The objective of this study was to evaluate the effect of variable ultrasound conditions on the permeation of diclofenac sodium DS with range of physicochemical properties through EpiDerm™.... Read More

September 16, 2022

Expression and Function of ABC Transporters in Human Alveolar Epithelial Cells

ATP-binding cassette (ABC) transporters are a large superfamily of membrane transporters that facilitate the translocation of different substrates. While ABC transporters are clearly expressed in various tumor cells where they can play a role in drug extrusion, the presence of... Read More

September 7, 2022

Anti-Glycation and Anti-Aging Properties of Resveratrol Derivatives in the in-vitro 3D Models of Human Skin

Purpose: Human skin undergoes modifications affecting its structural properties and barrier functions involved in protection against age-related damage. Glycation is a non-enzymatic reaction between macromolecules and sugars causing alterations to the elastic fibers and premature aging of the skin. Glycation... Read More

August 31, 2022

Correlation of In Vitro and In Vivo Skin Irritation Assays in Medical Devices: A Case Study

Biocompatibility testing is moving away from animal-based assays in favor of technologically advanced and reliable in silico and in vitro alternative approaches. While irritation has traditionally been assessed in a rabbit animal model, validated reconstructed human epidermis(RhE) models have been... Read More