Reference Libraries

December 11, 2015

NOVEL 3D HUMAN SMALL INTESTINAL TISSUE MODEL (EPIINESTINAL™ ) TO ASSESS DRUG PERMEATION & INFLAMMATION

Purpose: Drug transport and permeability across the small intestine (SMI) is a key parameter for determining bioavailability of orally administered drugs. The currently available in vitro models are highly dependent on immortalized cell lines (e.g. Caco-2) and have significant deficiencies... Read More

December 11, 2015

DISCOVERY OF TRANSDERMAL PENETRATION ENHANCERS BY HIGH-THROUGHPUT SCREENING.

Although transdermal drug delivery is more attractive than injection, it has not been applied to macromolecules because of low skin permeability. Here scientists at UC Santa Barbara describe particular mixtures of penetration enhancers that increase skin permeability to macromolecules (~1-10... Read More

December 11, 2015

PEPTIDE DRUG PERMEATION ENHANCEMENT BY SELECT CLASSES OF LIPIDS.

This study by researchers at Nastech Pharmaceuticals demonstrated that MatTek’s EpiAirway in vitro human tracheal/bronchial tissue equivalent can be used to identify lipids that rapidly and reversibly alter the tight junction permeability of human epithelial tissues. Tight junctions play an... Read More

December 11, 2015

LOCALIZATION OF P-GLYCOPROTEIN IN HYMAN TRACHEAL/BRONCHIAL EPITHELIAL CELL CULTURE (EPIAIRWAY™)

The development of a human in vitro cell culture system would enhance the ability to study various factors affecting nasal drug delivery. EpiAirway is a cell culture system derived from normal human tracheal/bronchial epithelial cells which is grown on polycarbonate... Read More

December 11, 2015

DEVELOPMENT OF A NOVEL HIGH-CONCENTRATION GALANTAMINE FORMULATION SUITABLE FOR INTRANASAL DELIVERY.

This study by researchers at Nastech Pharmaceuticals demonstrated that MatTek’s EpiAirway in vitro human tracheal/bronchial tissue equivalent can be used to assess the drug permeability and cellular toxicity of a novel drug formulation designed for intranasal delivery. The goal of... Read More

Reference Libraries

NOVEL 3D HUMAN SMALL INTESTINAL TISSUE MODEL (EPIINESTINAL™ ) TO ASSESS DRUG PERMEATION & INFLAMMATION

DISCOVERY OF TRANSDERMAL PENETRATION ENHANCERS BY HIGH-THROUGHPUT SCREENING.

PEPTIDE DRUG PERMEATION ENHANCEMENT BY SELECT CLASSES OF LIPIDS.

LOCALIZATION OF P-GLYCOPROTEIN IN HYMAN TRACHEAL/BRONCHIAL EPITHELIAL CELL CULTURE (EPIAIRWAY™)

DEVELOPMENT OF A NOVEL HIGH-CONCENTRATION GALANTAMINE FORMULATION SUITABLE FOR INTRANASAL DELIVERY.

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