Reference Libraries

PURPOSE: Exogenous melatonin (MT) has significant neuroprotective roles in Alzheimer’s and Parkinson’s diseases. This study investigates the delivery MT to brain via nasal route as a polymeric gel suspension using central brain microdialysis in anesthetized rats. METHODS: Micronized MT suspensions... Read More

This study by scientists at Nastech Pharmaceuticals demonstrated how MatTek’s EpiAirway human tracheal/bronchial tissue equivalent can be used to test the ability of a novel tight junction modulating (TJM) peptide to enhance the permeability of one low-molecular weight (LMW) drug... Read More

The development of a human in vitro cell culture system would enhance the ability to study various factors affecting nasal drug delivery. EpiAirway is a cell culture system derived from normal human tracheal/bronchial epithelial cells which is grown on polycarbonate... Read More

This study by researchers at Nastech Pharmaceuticals demonstrated that MatTek’s EpiAirway in vitro human tracheal/bronchial tissue equivalent can be used to identify lipids that rapidly and reversibly alter the tight junction permeability of human epithelial tissues. Tight junctions play an... Read More

This study by researchers at Nastech Pharmaceuticals demonstrated that MatTek’s EpiAirway in vitro human tracheal/bronchial tissue equivalent can be used to accurately assess the drug permeability, tight junction modulation, and cellular toxicity of new intranasal drug formulations. The purpose of... Read More