Reference Libraries

December 11, 2015

EARLY HOST RESPONSES OF SEASONAL AND PANDEMIC INFLUENZA A VIRUSES IN PRIMARY WELL-DIFFERENTIATED HUMAN LUNG EPITHELIAL CELLS

Replication, cell tropism and the magnitude of the host’s antiviral immune response each contribute to the resulting pathogenicity of influenza A viruses (IAV) in humans. In contrast to seasonal IAV in human cases, the 2009 H1N1 pandemic IAV (H1N1pdm) shows... Read More

December 11, 2015

PROTECTIVE EFFECT OF POMEGRANATE-DERIVED PRODUCTS ON UVB-MEDIATED DAMAGE IN HUMAN RECONSTITUTED SKIN.

Solar ultraviolet (UV) radiation, particularly its UVB (290–320 nm) component, is the primary cause of many adverse biological effects including photoageing and skin cancer. UVB radiation causes DNA damage, protein oxidation and induces matrix metalloproteinases (MMPs). Photochemoprevention via the use... Read More

December 11, 2015

XENOBIOTIC METABOLISM GENE EXPRESSION IN THE EPIDERM™ IN VITRO 3D HUMAN EPIDERMIS MODEL COMPARED TO HUMAN SKIN.

There is an urgent need to validate in vitro human skin models for use in safety testing. An important component of validation is characterizing the metabolizing capacity of these models. We report comparison of the expression of 139 genes encoding... Read More

December 11, 2015

LIPIDS INCLUDING CHOLESTERYL LINOLEATE AND CHOLESTERYL ARACHIDONATE CONTRIBUTE TO THE INHERENT ANTIBACTERIAL ACTIVITY OF HUMAN NASAL FLUID.

Mucosal surfaces provide first-line defense against microbial invasion through their complex secretions. The antimicrobial activities of proteins in these secretions have been well delineated, but the contributions of lipids to mucosal defense have not been defined. We found that normal... Read More

December 11, 2015

LTD4 INDUCES HB-EGF-DEPENDENT CXCL8 RELEASE THROUGH EGFR ACTIVATION IN HUMAN BRONCHIAL EPITHELIAL CELLS.

Airway epithelial cells release proinflammatory mediators that may contribute to airway remodeling and leukocyte recruitment. We explored the hypothesis that leukotriene D4 (LTD4) may trigger the release of proremodeling factors through activation of the EGF receptor (EGFR). We particularly focused... Read More

Reference Libraries

EARLY HOST RESPONSES OF SEASONAL AND PANDEMIC INFLUENZA A VIRUSES IN PRIMARY WELL-DIFFERENTIATED HUMAN LUNG EPITHELIAL CELLS

PROTECTIVE EFFECT OF POMEGRANATE-DERIVED PRODUCTS ON UVB-MEDIATED DAMAGE IN HUMAN RECONSTITUTED SKIN.

XENOBIOTIC METABOLISM GENE EXPRESSION IN THE EPIDERM™ IN VITRO 3D HUMAN EPIDERMIS MODEL COMPARED TO HUMAN SKIN.

LIPIDS INCLUDING CHOLESTERYL LINOLEATE AND CHOLESTERYL ARACHIDONATE CONTRIBUTE TO THE INHERENT ANTIBACTERIAL ACTIVITY OF HUMAN NASAL FLUID.

LTD4 INDUCES HB-EGF-DEPENDENT CXCL8 RELEASE THROUGH EGFR ACTIVATION IN HUMAN BRONCHIAL EPITHELIAL CELLS.

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