Reference Libraries

December 11, 2015

INCREASED HYALURONAN PRODUCTION AND DECREASED E-CADHERIN EXPRESSION BY CYTOKINE-STIMULATED KERATINOCYTES LEAD TO SPONGIOSIS FORMATION.

The pathogenesis of spongiosis, which is a well-known hallmark of acute eczema, is not fully understood. We sought to clarify the mechanism for the influx of tissue fluid into the epidermis and the loss of cohesion between keratinocytes in acute... Read More

December 11, 2015

THE TRANSPORT PROFILE OF CYTOKINES IN EPIDERMAL EQUIVALENTS SUBJECTED TO MECHANICAL LOADING.

This study by researchers at Eindhoven University of Technology and the University of London demonstrated how MatTek’s EpiDerm in vitro 3-D human skin tissue equivalent can be used to study the use of soft tissue cytokine release as potential biochemical... Read More

December 11, 2015

HUMAN INTESTINAL DENDRITIC CELLS DECREASE CYTOKINE RELEASE AGAINST SALMONELLA INFECTION IN THE PRESENCE OF LACTOBACILLUS PARACASEI UPON TLR ACTIVATION.

Probiotic bacteria have been shown to modulate immune responses and could have therapeutic effects in allergic and inflammatory disorders. However, little is known about the signaling pathways that are engaged by probiotics. Dendritic cells (DCs) are antigen-presenting cells that are... Read More

December 11, 2015

ASSURING SAFETY WITHOUT ANIMAL TESTING: DEVELOPMENT OF MECHANISTIC UNDERSTANDING OF DENDRITIC CELL ACTIVATION RESPONSE TO CHEMICAL SENSITISERS.

Assuring consumer safety without the generation of new animal data is currently a considerable challenge but one that we believe is ultimately achievable. Skin allergy (sensitisation) is an important consumer safety endpoint for home and personal care products and an... Read More

December 11, 2015

GENE EXPRESSION ANALYSIS OF DENDRITIC/LANGERHANS CELLS AND LANGERHANS CELL HISTIOCYTOSIS.

This study by researchers in the departments of Pathology and Laboratory Medicine, and Pediatric Oncology at the University of Groningen demonstrated that MatTek’s Human Langerhans/Dendritic Cells are an excellent in vitro model for studying the gene expression of Langerhans cell... Read More

Reference Libraries

INCREASED HYALURONAN PRODUCTION AND DECREASED E-CADHERIN EXPRESSION BY CYTOKINE-STIMULATED KERATINOCYTES LEAD TO SPONGIOSIS FORMATION.

THE TRANSPORT PROFILE OF CYTOKINES IN EPIDERMAL EQUIVALENTS SUBJECTED TO MECHANICAL LOADING.

HUMAN INTESTINAL DENDRITIC CELLS DECREASE CYTOKINE RELEASE AGAINST SALMONELLA INFECTION IN THE PRESENCE OF LACTOBACILLUS PARACASEI UPON TLR ACTIVATION.

ASSURING SAFETY WITHOUT ANIMAL TESTING: DEVELOPMENT OF MECHANISTIC UNDERSTANDING OF DENDRITIC CELL ACTIVATION RESPONSE TO CHEMICAL SENSITISERS.

GENE EXPRESSION ANALYSIS OF DENDRITIC/LANGERHANS CELLS AND LANGERHANS CELL HISTIOCYTOSIS.

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