Reference Libraries

December 11, 2015

XENOBIOTIC METABOLISM GENE EXPRESSION IN THE EPIDERM™ IN VITRO 3D HUMAN EPIDERMIS MODEL COMPARED TO HUMAN SKIN.

There is an urgent need to validate in vitro human skin models for use in safety testing. An important component of validation is characterizing the metabolizing capacity of these models. We report comparison of the expression of 139 genes encoding... Read More

December 11, 2015

PROTECTIVE EFFECT OF POMEGRANATE-DERIVED PRODUCTS ON UVB-MEDIATED DAMAGE IN HUMAN RECONSTITUTED SKIN.

Solar ultraviolet (UV) radiation, particularly its UVB (290–320 nm) component, is the primary cause of many adverse biological effects including photoageing and skin cancer. UVB radiation causes DNA damage, protein oxidation and induces matrix metalloproteinases (MMPs). Photochemoprevention via the use... Read More

December 11, 2015

CYTOKINE AND CHEMOKINE RELEASE UPON PROLONGED MECHANICAL LOADING OF THE EPIDERMIS.

This study by researchers at the Eindhoven University of Technology and the VU University Medical Center Dept. of Dermatology demonstrated that MatTek’s EpiDerm human epidermal tissue equivalent can be used to study the damage caused by subjecting these epidermal tissues... Read More

December 11, 2015

LTD4 INDUCES HB-EGF-DEPENDENT CXCL8 RELEASE THROUGH EGFR ACTIVATION IN HUMAN BRONCHIAL EPITHELIAL CELLS.

Airway epithelial cells release proinflammatory mediators that may contribute to airway remodeling and leukocyte recruitment. We explored the hypothesis that leukotriene D4 (LTD4) may trigger the release of proremodeling factors through activation of the EGF receptor (EGFR). We particularly focused... Read More

December 11, 2015

EXPRESSION OF STRATUM CORNEUM LIPID PATHWAYS IN HUMAN SKIN EQUIVALENT CULTURES.

This study by scientists at Procter & Gamble Beauty demonstrated that gene pathways involved in stratum corneum lipid formation are expressed in MatTek’s EpiDermFT full-thickness in vitro 3-D human skin tissue equivalent, suggesting that ths culture system is an appropriate... Read More

Reference Libraries

XENOBIOTIC METABOLISM GENE EXPRESSION IN THE EPIDERM™ IN VITRO 3D HUMAN EPIDERMIS MODEL COMPARED TO HUMAN SKIN.

PROTECTIVE EFFECT OF POMEGRANATE-DERIVED PRODUCTS ON UVB-MEDIATED DAMAGE IN HUMAN RECONSTITUTED SKIN.

CYTOKINE AND CHEMOKINE RELEASE UPON PROLONGED MECHANICAL LOADING OF THE EPIDERMIS.

LTD4 INDUCES HB-EGF-DEPENDENT CXCL8 RELEASE THROUGH EGFR ACTIVATION IN HUMAN BRONCHIAL EPITHELIAL CELLS.

EXPRESSION OF STRATUM CORNEUM LIPID PATHWAYS IN HUMAN SKIN EQUIVALENT CULTURES.

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