Reference Libraries

December 11, 2015

SYNERGISTIC ACTIONS OF PEMPHIGUS VULGARIS IGG, FAS-LIGAND AND TUMOR NECROSIS FACTOR-A DURING INDUCTION OF BASAL CELL SHRINKAGE AND ACANTHOLYSIS.

This study by researchers at the University of California at Davis demonstrated that when MatTek’s EpiDerm-FT epidermal/dermal human skin tissue equivalents were treated with pemphigus vulgaris (PV) IgGs, it resulted in suprabasilar epidermal clefting and the cell detachment pattern characteristic... Read More

December 11, 2015

HUMAN INTESTINAL DENDRITIC CELLS DECREASE CYTOKINE RELEASE AGAINST SALMONELLA INFECTION IN THE PRESENCE OF LACTOBACILLUS PARACASEI UPON TLR ACTIVATION.

Probiotic bacteria have been shown to modulate immune responses and could have therapeutic effects in allergic and inflammatory disorders. However, little is known about the signaling pathways that are engaged by probiotics. Dendritic cells (DCs) are antigen-presenting cells that are... Read More

December 11, 2015

COLCHICINE PROMOTES ANTIGEN CROSS-PRESENTATION BY MURINE DENDRITIC CELLS.

This study by researchers at the University of Texas Southwestern Medical Center demonstrated that MatTek’s Human Langerhans/Dendritic Cells are an excellent in vitro model for investigating and predicting the likely interactions of drugs (Colchicine) with human dendritic cells. Colchicine (COL)... Read More

December 11, 2015

ASSURING SAFETY WITHOUT ANIMAL TESTING: DEVELOPMENT OF MECHANISTIC UNDERSTANDING OF DENDRITIC CELL ACTIVATION RESPONSE TO CHEMICAL SENSITISERS.

Assuring consumer safety without the generation of new animal data is currently a considerable challenge but one that we believe is ultimately achievable. Skin allergy (sensitisation) is an important consumer safety endpoint for home and personal care products and an... Read More

December 11, 2015

DYNAMIC AND PHYSICAL CLUSTERING OF GENE EXPRESSION DURING EPIDERMAL BARRIER FORMATION IN DIFFERENTIATING KERATINOCYTES.

The mammalian epidermis is a continually renewing structure that provides the interface between the organism and an innately hostile environment. The keratinocyte is its principal cell. Keratinocyte proteins form a physical epithelial barrier, protect against microbial damage, and prepare immune... Read More

Reference Libraries

SYNERGISTIC ACTIONS OF PEMPHIGUS VULGARIS IGG, FAS-LIGAND AND TUMOR NECROSIS FACTOR-A DURING INDUCTION OF BASAL CELL SHRINKAGE AND ACANTHOLYSIS.

HUMAN INTESTINAL DENDRITIC CELLS DECREASE CYTOKINE RELEASE AGAINST SALMONELLA INFECTION IN THE PRESENCE OF LACTOBACILLUS PARACASEI UPON TLR ACTIVATION.

COLCHICINE PROMOTES ANTIGEN CROSS-PRESENTATION BY MURINE DENDRITIC CELLS.

ASSURING SAFETY WITHOUT ANIMAL TESTING: DEVELOPMENT OF MECHANISTIC UNDERSTANDING OF DENDRITIC CELL ACTIVATION RESPONSE TO CHEMICAL SENSITISERS.

DYNAMIC AND PHYSICAL CLUSTERING OF GENE EXPRESSION DURING EPIDERMAL BARRIER FORMATION IN DIFFERENTIATING KERATINOCYTES.

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