Reference Libraries

December 11, 2015

ROLE OF TOLL-LIKE RECEPTOR (TLR) ACTIVATION IN ASTHMA EXACERBATION: EXPERIMENTS WITH IN VITRO MODELS OF HUMAN AIRWAY EPITHELIAL CELLS (EPIAIRWAY) AND EPITHELIAL CELL/FIBROBLAST CO-CULTURES (EPIAIRWAY-FT).

This study by MatTek Corp. scientists demonstrated that MatTek’s EpiAirway and EpiAirway-FT in vitro human tracheal/bronchial tissue equivalents are excellent tools for performing mechanistic studies of signaling pathways related to asthma exacerbations. INTRODUCTION: Respiratory infections are a major cause of... Read More

December 11, 2015

REGULATION OF APOPTOSIS BY P53 IN UV-IRRADIATED HUMAN EPIDERMIS, PSORIATIC PLAQUES AND SENESCENT KERATINOCYTES.

This study by researchers at Loyola University Medical Center demonstrated that MatTek’s EpiDerm in vitro 3-D human skin tissue equivalent can be used to study the sensitivity and resistance of human epidermal keratinocytes to apoptosis when exposed to UV radiation.... Read More

December 11, 2015

HISTAMINE MAY INDUCE AIRWAY REMODELING THROUGH RELEASE OF EPIDERMAL GROWTH FACTOR RECEPTOR LIGANDS FROM BRONCHIAL EPITHELIAL CELLS

Asthma is a chronic inflammatory disease that is associated with airway remodeling, including hyperplasia of airway epithelial cells and airway smooth muscle cells, and goblet cell differentiation. We wished to address the potential role of histamine, a key biogenic amine... Read More

December 11, 2015

EXPRESSION OF 15-LIPOXYGENASE-2 IN THE EPIAIRWAY™ IN VITRO HUMAN TRACHEAL/BRONCHIAL EPITHELIAL MODEL: REGULATION BY TNF-α AND INF-γ.

15-Hydroxyeicosatetraenoic acid (15[S]-HETE) is the predominate arachidonic acid (AA) metabolite produced by human tracheal/bronchial tissue. This product of the 15-lipoxygenase (15-LOX) enzyme is believed to play a significant role in human airway inflammation and respiratory diseases including cystic fibrosis and... Read More

December 11, 2015

TUMOR NECROSIS FACTOR ALPHA (TNFα) INDUCTION OF THYMUS AND ACTIVATION REGULATED CHEMOKINE (TARC) EXPRESSION IS MEDIATED BY 15-LIPOXYGENASE 15-(LOX)-2 IN THE EPIAIRWAY™ HUMAN TRACHEAL/BRONCHIAL EPITHELIAL MODEL.

RATIONALE: T-Helper 2-type (TH2) T cells play a predominant role in human airway inflammation and asthma. TARC, a specific chemoattractant for TH2 cells, is induced by TNFα treatment of human airway cells, however, the cellular pathways involved in mediating TARC... Read More

Reference Libraries

ROLE OF TOLL-LIKE RECEPTOR (TLR) ACTIVATION IN ASTHMA EXACERBATION: EXPERIMENTS WITH IN VITRO MODELS OF HUMAN AIRWAY EPITHELIAL CELLS (EPIAIRWAY) AND EPITHELIAL CELL/FIBROBLAST CO-CULTURES (EPIAIRWAY-FT).

REGULATION OF APOPTOSIS BY P53 IN UV-IRRADIATED HUMAN EPIDERMIS, PSORIATIC PLAQUES AND SENESCENT KERATINOCYTES.

HISTAMINE MAY INDUCE AIRWAY REMODELING THROUGH RELEASE OF EPIDERMAL GROWTH FACTOR RECEPTOR LIGANDS FROM BRONCHIAL EPITHELIAL CELLS

EXPRESSION OF 15-LIPOXYGENASE-2 IN THE EPIAIRWAY™ IN VITRO HUMAN TRACHEAL/BRONCHIAL EPITHELIAL MODEL: REGULATION BY TNF-α AND INF-γ.

TUMOR NECROSIS FACTOR ALPHA (TNFα) INDUCTION OF THYMUS AND ACTIVATION REGULATED CHEMOKINE (TARC) EXPRESSION IS MEDIATED BY 15-LIPOXYGENASE 15-(LOX)-2 IN THE EPIAIRWAY™ HUMAN TRACHEAL/BRONCHIAL EPITHELIAL MODEL.

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