Reference Libraries

December 11, 2015

TUMOR NECROSIS FACTOR ALPHA (TNFα) INDUCTION OF THYMUS AND ACTIVATION REGULATED CHEMOKINE (TARC) EXPRESSION IS MEDIATED BY 15-LIPOXYGENASE 15-(LOX)-2 IN THE EPIAIRWAY™ HUMAN TRACHEAL/BRONCHIAL EPITHELIAL MODEL.

RATIONALE: T-Helper 2-type (TH2) T cells play a predominant role in human airway inflammation and asthma. TARC, a specific chemoattractant for TH2 cells, is induced by TNFα treatment of human airway cells, however, the cellular pathways involved in mediating TARC... Read More

December 11, 2015

ROLE OF TOLL-LIKE RECEPTOR (TLR) ACTIVATION IN ASTHMA EXACERBATION: EXPERIMENTS WITH IN VITRO MODELS OF HUMAN AIRWAY EPITHELIAL CELLS (EPIAIRWAY) AND EPITHELIAL CELL/FIBROBLAST CO-CULTURES (EPIAIRWAY-FT).

This study by MatTek Corp. scientists demonstrated that MatTek’s EpiAirway and EpiAirway-FT in vitro human tracheal/bronchial tissue equivalents are excellent tools for performing mechanistic studies of signaling pathways related to asthma exacerbations. INTRODUCTION: Respiratory infections are a major cause of... Read More

December 11, 2015

VISUALIZATION AND CHARACTERIZATION OF UVB-INDUCED REACTIVE OXYGEN SPECIES IN A HUMAN SKIN EQUIVALENT MODEL.

This study by researchers at Procter and Gamble, Kyoto University and Kyoto Pharmaceutical University demonstrated that MatTek’s EpiDerm in vitro 3-D human skin tissue equivalent is useful for visualizing the production of UVB-induced Reactive Oxygen Species (ROS) in real-time, and... Read More

December 11, 2015

RECONSTRUCTED, DIFFERENTIATED AIRWAY EPITHELIAL CULTURES TO DETECT OCCUPATIONAL ASTHMA CAUSING AGENTS.

Normal human tracheal-bronchial epithelial cells (NHBE) have been cultured using serum free medium to form a three dimensional tissue-like structure that closely resembles the epithelial tissue of the respiratory tract. Histological cross-sections of both the in vitro tissue and a... Read More

December 11, 2015

BY IL-1 SIGNALING, MONOCYTE-DERIVED CELLS DRAMATICALLY ENHANCE THE EPIDERMAL ANTIMICROBIAL RESPONSE TO LIPOPOLYSACCHARIDE.

Epithelia react to microbial pathogens by mounting a defensive response that includes the production of antimicrobial peptides. In this study, we show that, in human epidermal cultures, Escherichia coli LPS was a very weak direct inducer of human β-defensin (HBD)-2... Read More

Reference Libraries

TUMOR NECROSIS FACTOR ALPHA (TNFα) INDUCTION OF THYMUS AND ACTIVATION REGULATED CHEMOKINE (TARC) EXPRESSION IS MEDIATED BY 15-LIPOXYGENASE 15-(LOX)-2 IN THE EPIAIRWAY™ HUMAN TRACHEAL/BRONCHIAL EPITHELIAL MODEL.

ROLE OF TOLL-LIKE RECEPTOR (TLR) ACTIVATION IN ASTHMA EXACERBATION: EXPERIMENTS WITH IN VITRO MODELS OF HUMAN AIRWAY EPITHELIAL CELLS (EPIAIRWAY) AND EPITHELIAL CELL/FIBROBLAST CO-CULTURES (EPIAIRWAY-FT).

VISUALIZATION AND CHARACTERIZATION OF UVB-INDUCED REACTIVE OXYGEN SPECIES IN A HUMAN SKIN EQUIVALENT MODEL.

RECONSTRUCTED, DIFFERENTIATED AIRWAY EPITHELIAL CULTURES TO DETECT OCCUPATIONAL ASTHMA CAUSING AGENTS.

BY IL-1 SIGNALING, MONOCYTE-DERIVED CELLS DRAMATICALLY ENHANCE THE EPIDERMAL ANTIMICROBIAL RESPONSE TO LIPOPOLYSACCHARIDE.

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