Reference Libraries

December 11, 2015

EXPRESSION OF 15-LIPOXYGENASE-2 IN THE EPIAIRWAY™ IN VITRO HUMAN TRACHEAL/BRONCHIAL EPITHELIAL MODEL: REGULATION BY TNF-α AND INF-γ.

15-Hydroxyeicosatetraenoic acid (15[S]-HETE) is the predominate arachidonic acid (AA) metabolite produced by human tracheal/bronchial tissue. This product of the 15-lipoxygenase (15-LOX) enzyme is believed to play a significant role in human airway inflammation and respiratory diseases including cystic fibrosis and... Read More

December 11, 2015

TUMOR NECROSIS FACTOR ALPHA (TNFα) INDUCTION OF THYMUS AND ACTIVATION REGULATED CHEMOKINE (TARC) EXPRESSION IS MEDIATED BY 15-LIPOXYGENASE 15-(LOX)-2 IN THE EPIAIRWAY™ HUMAN TRACHEAL/BRONCHIAL EPITHELIAL MODEL.

RATIONALE: T-Helper 2-type (TH2) T cells play a predominant role in human airway inflammation and asthma. TARC, a specific chemoattractant for TH2 cells, is induced by TNFα treatment of human airway cells, however, the cellular pathways involved in mediating TARC... Read More

December 11, 2015

TH2 CYTOKINE STIMULATED AIRWAY EPITHELIAL CELLS DEMONSTRATE GRANULE-DEPENDENT FasL LOCALIZATION.

This study by researchers at St. Paul’s Hospital / University of British Columbia demonstrated how MatTek’s EpiAirway human airway tissue equivalent can be used to investigate if the localization and presentation of an airway epithelial cell constituent, Fas Ligand (FasL),... Read More

December 11, 2015

AN IN VITRO MODEL OF FULL-THICKNESS HUMAN AIRWAY EPITHELIUM (EPIAIRWAY-FT) FOR STUDY OF EPITHELIUM/MATRIX INTERACTIONS.

In vitro models of airway epithelium (AE) have potential utility for study of diseases such as asthma and COPD, development of inhalable therapeutics, and toxicology of hazardous chemicals. However, degradation and remodeling of subepithelial stromal tissue are important aspects of... Read More

December 11, 2015

APPLICATION OF ORGANOTYPIC IN VITRO HUMAN CELL CULTURE MODELS FOR RESEARCH AND DEVELOPMENT OF INHALATION PHARMACEUTICAL FORMULATIONS TARGETING THE PROXIMAL AIRWAYS.

Delivery of pharmaceuticals via inhalation is a potentially useful alternative to intravenous injection for drugs that are unstable or poorly absorbed after oral administration; for chronic disease conditions that require frequent administration: or therapeutics for which the airways are the... Read More

Reference Libraries

EXPRESSION OF 15-LIPOXYGENASE-2 IN THE EPIAIRWAY™ IN VITRO HUMAN TRACHEAL/BRONCHIAL EPITHELIAL MODEL: REGULATION BY TNF-α AND INF-γ.

TUMOR NECROSIS FACTOR ALPHA (TNFα) INDUCTION OF THYMUS AND ACTIVATION REGULATED CHEMOKINE (TARC) EXPRESSION IS MEDIATED BY 15-LIPOXYGENASE 15-(LOX)-2 IN THE EPIAIRWAY™ HUMAN TRACHEAL/BRONCHIAL EPITHELIAL MODEL.

TH2 CYTOKINE STIMULATED AIRWAY EPITHELIAL CELLS DEMONSTRATE GRANULE-DEPENDENT FasL LOCALIZATION.

AN IN VITRO MODEL OF FULL-THICKNESS HUMAN AIRWAY EPITHELIUM (EPIAIRWAY-FT) FOR STUDY OF EPITHELIUM/MATRIX INTERACTIONS.

APPLICATION OF ORGANOTYPIC IN VITRO HUMAN CELL CULTURE MODELS FOR RESEARCH AND DEVELOPMENT OF INHALATION PHARMACEUTICAL FORMULATIONS TARGETING THE PROXIMAL AIRWAYS.

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