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May 27, 2022

Mitoxantrone modulates a heparan sulfate‑spike complex to inhibit SARS‑CoV‑2 infection

Spike-mediated entry of SARS-CoV-2 into human airway epithelial cells is an attractive therapeutic target for COVID-19. In addition to protein receptors, the SARS-CoV-2 spike (S) protein also interacts with heparan sulfate, a negatively charged glycosaminoglycan (GAG) attached to certain membrane... Read More

May 27, 2022

A Novel Macrophage Containing Organotypic Small Intestinal Tissue for Modeling Gut Inflammation

As gatekeepers of intestinal immunehomeostasis, macrophages play a critical role in inflammation in the gut. In this study, were constructed a new macrophage-containing primary cell-based full-thickness small intestinal(SMI+M) tissue model and characterized it for:1) macrophage incorporation (immunohistochemistry, IHC), 2) barrier... Read More

May 10, 2022

Can Performance and Gentleness Be Reconciled? A Skin Care Approach for Sensitive Skin

People with self-reported sensitive skin may reluctantly use performing anti-ageing skin care products as it could elicit skin discomfort. We thus aimed to design and test an anti-ageing skin care routine that is suitable for people reporting sensitive skin. Key... Read More

May 10, 2022

Replication and antiviral activity of MERS and SARS-CoV-2 variants in a highly specialized 3D mucociliary tissue model consisting of normal human-derived tracheal/bronchial epithelial cells

In vitro assays are an important early step to determine the potential antiviral activity of novel compounds. The antiviral efficacy of compounds is often evaluated in immortalized cell lines, which offer the advantage of cost effectiveness, ease of use, and... Read More

May 10, 2022

Cytokine induction in the 3D EpiDerm™ skin model used as an in vitro preclinical screening tool for formulations with anti-inflammatory action

Abnormal cytokine profiles represent the hallmark of inflammatory skin conditions such as psoriasis, acne, atopic dermatitis, irritant and allergic contact dermatitis. Damage to skin keratinocytes induces the release of primary cytokine interleukin (IL)-1α which further stimulates the release of secondary... Read More

Reference Libraries

Mitoxantrone modulates a heparan sulfate‑spike complex to inhibit SARS‑CoV‑2 infection

A Novel Macrophage Containing Organotypic Small Intestinal Tissue for Modeling Gut Inflammation

Can Performance and Gentleness Be Reconciled? A Skin Care Approach for Sensitive Skin

Replication and antiviral activity of MERS and SARS-CoV-2 variants in a highly specialized 3D mucociliary tissue model consisting of normal human-derived tracheal/bronchial epithelial cells

Cytokine induction in the 3D EpiDerm™ skin model used as an in vitro preclinical screening tool for formulations with anti-inflammatory action

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