Reference Libraries

September 16, 2022

Expression and Function of ABC Transporters in Human Alveolar Epithelial Cells

ATP-binding cassette (ABC) transporters are a large superfamily of membrane transporters that facilitate the translocation of different substrates. While ABC transporters are clearly expressed in various tumor cells where they can play a role in drug extrusion, the presence of... Read More

September 7, 2022

Anti-Glycation and Anti-Aging Properties of Resveratrol Derivatives in the in-vitro 3D Models of Human Skin

Purpose: Human skin undergoes modifications affecting its structural properties and barrier functions involved in protection against age-related damage. Glycation is a non-enzymatic reaction between macromolecules and sugars causing alterations to the elastic fibers and premature aging of the skin. Glycation... Read More

August 31, 2022

Correlation of In Vitro and In Vivo Skin Irritation Assays in Medical Devices: A Case Study

Biocompatibility testing is moving away from animal-based assays in favor of technologically advanced and reliable in silico and in vitro alternative approaches. While irritation has traditionally been assessed in a rabbit animal model, validated reconstructed human epidermis(RhE) models have been... Read More

August 24, 2022

Congeners-Specific Intestinal Absorption Of Microcystins In An In Vitro 3D Human Intestinal Epithelium: The Role Of Influx/Efflux Transporters

Microcystins constitute a group of over 200 variants and are increasingly considered as emerging toxins in food and feed safety, particularly with regards to sea-food and fish consumption. Toxicity of MCs is congener-specific, being characterised by different acute potencies, likely... Read More