Reference Libraries

December 11, 2015

PLASMACYTOID DENDRITIC CELL-BASED ASSAY AS AN IN VITRO ALTERNATIVE FOR CHEMICAL ALLERGENICITY SCREENING.

Human dendritic cells (DC) have been used as an alternative to existing animal models utilized throughout industry to monitor products for contact sensitization. Such methods are necessary to comply with the ban on animal testing imposed by the Cosmetics Directive... Read More

December 11, 2015

A PLASMACYTOID DENDRITIC CELL (CD123+/CD11c−) BASED ASSAY SYSTEM TO PREDICT CONTACT ALLERGENICITY OF CHEMICALS.

This study by scientists at MatTek Corp. demonstrated that CD86 expression in the plasmacytoid Dendritic Cell (pDC) fraction of MatTek’s Human Dendritic Cells is a sensitive and specific indicator of contact allergenicity, and that an assay method utilizing normal human... Read More

December 11, 2015

HARVEST, PROLIFERATION, AND FUNCTIONAL TESTING OF HUMAN DENDRITIC CELLS.

Purpose: Difficulty in harvesting large numbers of cells, short survival time, and rapid phenotypic changes in culture have prevented the widespread use of human dendritic cells (DC) for many fundamental studies applicable to the initial stages of pharmaceutical discovery and... Read More

December 11, 2015

CYTOKINE RESPONSE OF THE EPIDERM SKIN MODEL TO TOPICALLY APPLIED IRRITANTS AND TOXICANTS.

EpiDerm™, MatTek Corporation’s in vitro reproduction of the human epidermis provides a convenient way in which toxicity and irritation potential of chemicals and physical stresses can be assessed. Derived from single strains of human keratinocytes, the model contains layers of... Read More

December 11, 2015

NORMAL HUMAN DENDRITIC CELLS: A TOOL TO STUDY ALLERGIC AND IMMUNOLOGICAL REACTIONS IN VITRO.

Dendritic cells (DC) or Langerhans cells (LC) are immunological cells of the body which play a key role in allergic reactions and infectious diseases. However, widespread experimental use of DC has not occurred since previously-used methods of harvesting DC directly... Read More

Reference Libraries

PLASMACYTOID DENDRITIC CELL-BASED ASSAY AS AN IN VITRO ALTERNATIVE FOR CHEMICAL ALLERGENICITY SCREENING.

A PLASMACYTOID DENDRITIC CELL (CD123+/CD11c−) BASED ASSAY SYSTEM TO PREDICT CONTACT ALLERGENICITY OF CHEMICALS.

HARVEST, PROLIFERATION, AND FUNCTIONAL TESTING OF HUMAN DENDRITIC CELLS.

CYTOKINE RESPONSE OF THE EPIDERM SKIN MODEL TO TOPICALLY APPLIED IRRITANTS AND TOXICANTS.

NORMAL HUMAN DENDRITIC CELLS: A TOOL TO STUDY ALLERGIC AND IMMUNOLOGICAL REACTIONS IN VITRO.

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