Reference Libraries

The study aimed at evaluating tissue architecture and quality of the permeability barrier in commercially available reconstructed human skin models; EpiDerm™, SkinEthic™ and Episkin™ in comparison to native tissue. For this purpose, tissue architecture was examined by electron microscopy and... Read More

The stratum corneum is the outermost layer of the skin and as such represents the decisive barrier between the body and the environment. The combination of horny cells and lamellar lipid layers prevents water loss from the body and protects... Read More

Human skin models, such as EpiDerm® and Episkin® are not easily mounted into static or dynamic diffusion cells that are commonly used to perform bioavailability studies with human skin ex vivo. For various reasons, such as fragility, small sample size,... Read More

As part of a Colgate-Palmolive sponsored program to validate an in vitro percutaneous absorption model, three reference materials with extensive in vivo human and in vitro (animal and human) data were evaluated in three in vitro models. The objective of... Read More