Reference Libraries

Physiological structures associated with iontophoretic paths in hairless mouse skin and two cultured skin models (“EpiDerm” by Mattek, Corp., and “SKIN” by Advanced Tissue Sciences, Inc.) are reported. Visualization of ionic paths at current densities between 20 and 100 uA/cm2... Read More

Zinc sulfate monohydrate is a widely used agent in the pharmaceutical industry. It can be applied on the skin in the form of a solution, ointment, or lotion, and recently in the form of non-woven fabrics impregnated with zinc sulfate... Read More

The study aimed at evaluating tissue architecture and quality of the permeability barrier in commercially available reconstructed human skin models; EpiDerm™, SkinEthic™ and Episkin™ in comparison to native tissue. For this purpose, tissue architecture was examined by electron microscopy and... Read More

Until now there is no general guideline to study the penetration of foreign substances into the skin and there are several in vitro models to study topical dermatological dosage forms. Excised human skin has proven to be one of the... Read More

As part of a Colgate-Palmolive sponsored program to validate an in vitro percutaneous absorption model, three reference materials with extensive in vivo human and in vitro (animal and human) data were evaluated in three in vitro models. The objective of... Read More