Reference Libraries

June 23, 2022

In vitro -in vivo assay validation for vaginal irritation of chemicals

The goal of the study is to validate the utility of the 3D human in vitro vaginal tissue model as an alternate for rabbit vaginal irritation using a set of coded test articles (TAs). A double-blinded study was conducted in... Read More

May 27, 2022

Interaction of Gardnerella vaginalis and Vaginolysin with the Apical versus Basolateral Face of a Three-Dimensional Model of Vaginal Epithelium

Studies have implicated Gardnerella vaginalis as an important etiological agent in bacterial vaginosis (BV). It produces a cholesterol-dependent cytolysin, vaginolysin (VLY). In this study, we sought to characterize the interaction between vaginal epithelium, G. vaginalis, and VLY using EpiVaginal tissues... Read More

May 27, 2022

Cytotoxicity, oxidative stress, and inflammatory response of smokeless tobacco extracts and cytotoxicity of combustible cigarette whole smoke in a 3D oral organotypic buccal cell model

Oral disease is frequently associated with viral and environmental exposures and oral hygiene. The use of tobacco is a risk factor in the development of oral disease. Cytotoxicity, inflammatory response, and oxidative stress have been reported to have a role... Read More

May 27, 2022

Mitoxantrone modulates a heparan sulfate‑spike complex to inhibit SARS‑CoV‑2 infection

Spike-mediated entry of SARS-CoV-2 into human airway epithelial cells is an attractive therapeutic target for COVID-19. In addition to protein receptors, the SARS-CoV-2 spike (S) protein also interacts with heparan sulfate, a negatively charged glycosaminoglycan (GAG) attached to certain membrane... Read More

May 27, 2022

A Novel Macrophage Containing Organotypic Small Intestinal Tissue for Modeling Gut Inflammation

As gatekeepers of intestinal immunehomeostasis, macrophages play a critical role in inflammation in the gut. In this study, were constructed a new macrophage-containing primary cell-based full-thickness small intestinal(SMI+M) tissue model and characterized it for:1) macrophage incorporation (immunohistochemistry, IHC), 2) barrier... Read More

Reference Libraries

In vitro -in vivo assay validation for vaginal irritation of chemicals

Interaction of Gardnerella vaginalis and Vaginolysin with the Apical versus Basolateral Face of a Three-Dimensional Model of Vaginal Epithelium

Cytotoxicity, oxidative stress, and inflammatory response of smokeless tobacco extracts and cytotoxicity of combustible cigarette whole smoke in a 3D oral organotypic buccal cell model

Mitoxantrone modulates a heparan sulfate‑spike complex to inhibit SARS‑CoV‑2 infection

A Novel Macrophage Containing Organotypic Small Intestinal Tissue for Modeling Gut Inflammation

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