Reference Libraries

January 7, 2022

Use of alternative test methods in a tiered testing approach to address photoirritation potential of fragrance materials

The safety assessment of fragrance materials for photoirritation utilized by The Research Institute for Fragrance Materials has recently been modified and is described in detail. Materials demonstrating significant absorbance in the ultraviolet and visible light (UV/VIS) range (290–700 nm) may... Read More

January 7, 2022

Flagellin From Pseudomonas Aeruginosa Stimulates ATBº,+ Transporter for Arginine and Neutral Amino Acids in Human Airway Epithelial Cells

At present, the central role played by arginine in the modulation of the inflammatory cellular responses is well-recognized, and many pro-inflammatory stimuli are known to modulate the expression and activity of its transmembrane transporters. In this regard, we have addressed... Read More

January 3, 2022

Cellular Lysosomes’ Activity for Melanin Reduction on Artifcial Skin Tissue

All eukaryotes have lysosomes which contain hydrolytic enzymes such as protease to degrade waste materials and cellular fragments. As a cellular organelle, lysosomes function as the digestive system of the cell, serving both to degrade material taken up from outside... Read More

January 3, 2022

Novel Vaginal Microflora Colonization Model Providing New Insight into Microbicide Mechanism of Action

Several broad-spectrum microbicides, including cellulose sulfate (CS), have passed conventional preclinical and phase I clinical safety evaluation and yet have failed to protect women from acquiring IDV -1 in phase II/Ill trials. Concerns have been raised that current preclinical algorithms... Read More

January 3, 2022

In vitro models replicating the human intestinal epithelium for absorption and metabolism studies: A systematic review

Absorption, distribution, metabolism and excretion (ADME) studies represent a fundamental step in the early stages of drug discovery. In particular, the absorption of orally administered drugs, which occurs at the intestinal level, has gained attention since poor oral bioavailability often... Read More

Reference Libraries

Use of alternative test methods in a tiered testing approach to address photoirritation potential of fragrance materials

Flagellin From Pseudomonas Aeruginosa Stimulates ATBº,+ Transporter for Arginine and Neutral Amino Acids in Human Airway Epithelial Cells

Cellular Lysosomes’ Activity for Melanin Reduction on Artifcial Skin Tissue

Novel Vaginal Microflora Colonization Model Providing New Insight into Microbicide Mechanism of Action

In vitro models replicating the human intestinal epithelium for absorption and metabolism studies: A systematic review

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