Reference Libraries

June 16, 2021

Microvesicating effects of sulfur mustard on an in vitro human skin model

Bis-(b-chloroethyl) sulfide (SM) is a potent skin vesicant previously used for chemical warfare. Progress in determination of the mechanistic basis of SM pathology, and development of prophylactic and/or therapeutic countermeasures to SM exposure has been hampered by lack of physiologically... Read More

May 27, 2021

Experiments in the EpiDerm 3D Skin In Vitro Model and Minipigs In Vivo Indicate Comparatively Lower In Vivo Skin Sensitivity of Topically Applied Aneugenic Compounds

Risk management of in vitro aneugens for topically applied compounds is not clearly defined because there is no validated methodology to accurately measure compound concentration in proliferating stratum basale keratinocytes of the skin. Here, we experimentally tested several known aneugens... Read More

May 27, 2021

Multidose evaluation of 6,710 drug repurposing library identifies potent SARS-CoV-2 infection inhibitors In Vitro and In Vivo

The SARS-CoV-2 pandemic has caused widespread illness, loss of life, and socioeconomic disruption that is unlikely to resolve until vaccines are widely adopted, and effective therapeutic treatments become established. Here, a well curated and annotated library of 6710 clinical and... Read More

April 20, 2021

Potent Antiviral Activity against HSV-1 and SARS-CoV-2 by Antimicrobial Peptoids

Viral infections, such as those caused by Herpes Simplex Virus-1 (HSV-1) and SARS-CoV-2, affect millions of people each year. However, there are few antiviral drugs that can effectively treat these infections. The standard approach in the development of antiviral drugs... Read More

April 8, 2021

Retrospective review on in vitro phototoxicity data generated in 3D skin models to support the development of new OECD Test Guideline

Phototoxicity (also photo-irritation), is a light-induced skin reaction that occurs when photoreactive chemicals are activated to produce cytotoxic effects. Phototoxicity testing of chemicals is mostly conducted in vitro, following the methods described in the OECD test guideline (OECD TG 432),... Read More