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January 11, 2021

Influenza A Virus Infection of Human Respiratory Cells Induces Primary MicroRNA Expression*

The cellular response to virus infection is initiated by recognition of the invading pathogen and subsequent changes in gene expression mediated by both transcriptional and translational mechanisms. In addition to well established means of regulating antiviral gene expression, it has... Read More

January 11, 2021

A Systems Biology Approach Reveals the Dose- and Time-Dependent Effect of Primary Human Airway Epithelium Tissue Culture After Exposure to Cigarette Smoke In Vitro

To establish a relevant in vitro model for systems toxicology-based mechanistic assessment of environmental stressors such as cigarette smoke (CS), we exposed human organotypic bronchial epithelial tissue cultures at the air liquid interface (ALI) to various CS doses. Previously, we... Read More

January 11, 2021

In vitro evaluation of immunobiological activity of simple mannolipids

Immunomodulation, cytotoxicity and anti-cancer activity of selected amphiphilic non-ionic (thio)alkyl α-Dmannosides (with aglycone of C6-C12) were investigated in vitro in human cervix epitheloid carcinoma cell line HeLa, murine melanoma cancer cells B16, murine lymphocytic leukemia cell line L1210, murine fibroblast... Read More

December 10, 2020

Novel cytokine marker available for skin irritation testing of medical devices using reconstructed human epidermis models

In biological safety evaluation of medical devices, false-negative results have been observed during skin irritation testing using the reconstructed human epidermis (RhE) model when measuring cell viability as a single marker. Therefore, to improve testing accuracy, this study conducted a... Read More

December 10, 2020

The expression of gingival epithelial junctions in response to subgingival biofilms

Periodontitis is an infectious inﬂammatory disease that destroys the tooth-supporting tissues. It is caused by the formation of subgingival bioﬁlms on the surface of the tooth. Characteristic bacteria associated with subgingival bioﬁlms are the Gram-negative anaerobes Porphyromonas gingivalis, Tannerella forsythia... Read More

Reference Libraries

Influenza A Virus Infection of Human Respiratory Cells Induces Primary MicroRNA Expression*

A Systems Biology Approach Reveals the Dose- and Time-Dependent Effect of Primary Human Airway Epithelium Tissue Culture After Exposure to Cigarette Smoke In Vitro

In vitro evaluation of immunobiological activity of simple mannolipids

Novel cytokine marker available for skin irritation testing of medical devices using reconstructed human epidermis models

The expression of gingival epithelial junctions in response to subgingival biofilms

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